新方法制备不溶性丝素薄膜及其性质研究  

Preparation and Properties of Insoluble Fibroin Films by Novel Method

作　　者：吕强[1] 曹传宝[1] 张瑛[1] 马西兰[1] 朱鹤孙[1] 

机构地区：[1]北京理工大学材料科学研究中心,北京100081

出　　处：《高等学校化学学报》2004年第9期1752-1755,共4页Chemical Journal of Chinese Universities

基　　金：国家"九七三"计划项目 (批准号 :G19990 64 70 5 );国家"八六三"项目 (批准号 :2 0 0 2 A A3 2 60 3 0 )资助

摘　　要：报道一种制备不溶性丝素蛋白薄膜的新方法 .在温和搅拌下 ,将丝素溶液浓缩至 1 6% ,通过调整干燥温度和干燥速率 ,直接获得不溶于水的丝素薄膜 .薄膜结构通过 FTIR-ATR和 XRD测定 ,同时对薄膜的机械性能进行研究 .结果表明 ,丝素薄膜在干燥温度高于 60℃时 ,有充足的 β折叠结构存在 ,机械性能良好 .当干燥温度为 70℃时 ,材料的拉伸强度和断裂伸长率分别为 2 9.8MPa和 5 9.6% ,远远强于经过甲醇处理的丝素薄膜的机械性能 .当干燥温度高于 60℃时 ,材料在水中具有优异的稳定性 .由于在丝素薄膜的制备中避免了甲醇的使用并使材料具有更好的机械性能 ,此方法制备的丝素薄膜更为安全 ,应用会更广泛 .A novel method for preparing the insoluble fibroin films was developed. After the fibroin solution was concentrated to about 16% with mild stirring at 45-50 ℃, the insoluble fibroin films could directly obtained by adjusting drying temperature and drying rate. The FTIR-ATR, XRD were used to study the structure change of fibroin films. The physical and mechanical properties were investigated to discover the feasibility of using these films as biomedical materials. When the fibroin obtained at above 60 ℃, abundant β-sheet crystal existed in fibroin films. The tensile strength and breaking elongation of films dried at 70 ℃ were 29.8 MPa and 59.6%, which distinctly superior to the fibroin films treated with methanol. Considering the excellent mechanical properties and avoidance of methanol treatment, the fibroin films prepared with this method were more useful and safer.

关 键 词：丝素蛋白 机械性能 不溶性 

分 类 号：O631[理学—高分子化学]