缺氧缺血性脑病新生儿纳洛酮治疗前后血浆β-内啡肽的改变(英文)  

Alteration of serum beta-endorphin before and after the treatment of naloxone in neonates with hypoxic-ischemic encephalopathy

作　　者：唐兰芬[1] 陈铭珍[1] 孟琼[1] 苏赞彩[1] 揭育丽 

机构地区：[1]广东医学院附属医院儿科,广东省湛江市524001 [2]广东医学院附属医院同位素科,广东省湛江市524001

出　　处：《中国临床康复》2004年第27期5998-5999,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:脑缺氧缺血可激活一系列生物反应,引起神经元内多种物质的表达变化,从而进一步介导脑组织的损伤,β-内啡肽是否参与了纳洛酮对新生儿缺氧缺血性脑病(hypoxic-ischemicencephalopathy,HIE)治疗的过程,目前研究较少。目的:观察纳洛酮治疗前后血浆β-内啡肽改变,探讨纳洛酮治疗对新生儿HIE的保护作用。设计:以诊断为依据的非随机对照研究。地点和对象:1996-10/1997-10广东医学院附属医院新生儿病房HIE患儿38例(HIE组),男26例,女12例,均为足月儿。25例正常新生儿(正常新生儿组)选自广东医学院附属医院产科婴儿室正常分娩的足月儿,男15例,女10例。干预:38例患儿分别于出生72h内(急性期,治疗前)和7～10d时(恢复期)及25例正常新生儿(出生72h内)血浆β-内啡肽进行检测,并将38例HIE患儿随机分为纳洛组和非纳洛酮组,观察两组的临床疗效及治疗前后血浆β-内啡肽的改变。主要观察指标:各组患儿血浆β-内啡肽的含量。结果:38例HIE患儿急性期血浆β—内啡肽水平较25例正常新生儿显著增高犤(620.35±140.92)ng/L,(373.70±146.69)ng/L,t=6.16,P<0.01犦,恢复期与正常新生儿比较差异无显著性意义犤(335.34±160.37)ng/L,(373.70±146.69)ng/L,P>0.05犦。纳洛酮组与非纳洛酮组治疗前后血浆β-内啡肽浓度差值比较未见?BACKGROUND:Cerebral hypoxic ischemia could activate serials of biologic reactions and induce the changes in the expressions of multiple substances in neurons,which thereby further mediates injuries in brain tissues. There are few researches at present regarding to whether β endorphin participates in the therapeutic process of naloxone in the treatment of neonatal hypoxic ischemic encephalopathy(HIE). OBJECTIVE:To observe the alteration of serum beta endorphin(β endorphin) before and after the treatment of naloxone for the discussion of the protective effects of naloxone in neonatal HIE. DESIGN:A non randomised controlled trial based on diagnosis. SETTING and PARTICIPANTS:A total of 38 mature infants with HIE were selected into HIE group from the department of neonate of Guangdong Medical University Affiliated Hospital during October 1996 to October 1997 including 26 male and 12 female cases.25 normal mature neonates were selected into normal group from the Infant Room of Obstetrical Department, Affiliated Hospital of Guangdong Medical College,including 15 male and 10 male subjects. INTERVENTIONS:Serum β endorphin was detected within 72 hours after born(acute stage,before therapy) and at 7 to 10 days(recovery period) respectively in 38 HIE neonates, and within 72 hours after born in 25 normal neonates as well.38 HIE neonates were randomly allocated into naloxone group and non naloxone group for the observation of the clinical therapeutic effectiveness and the alteration of serum β endorphin before and after therapy.Main outcome measures: serum content of β endorphin in neonates of each group. RESULTS:Serum β endorphin significantly elevated at acute stage in 38 HIE neonates compared with that of 25 normal neonates[(620.35±140.92) ng/L,(373.70±146.69) ng/L,t=6.16,P< 0.01],but no significant difference in recovery period between HIE and normal neonates [(335.34±160.37) ng/L,(373.70±146.69) ng/L,P >0.05].There was no significance in the comparison of differences of serum β endorphin before

关 键 词：脑缺血/病理生理学 脑缺氧/病理生理学 婴儿 新生 疾病 Β-内啡肽 纳洛酮 

分 类 号：R722.1[医药卫生—儿科]