抗生素作用下带质粒与非带质粒菌群的动力学分析  

Analysis of dynamics on plasmid-bearing and plasmid-free bacteria under the influence of antibiotics

作　　者：王开发[1] 樊爱军[1] 邓国宏[2] 

机构地区：[1]第三军医大学基础医学部数学教研室,重庆400038 [2]第三军医大学附属西南医院全军感染病研究所,重庆400038

出　　处：《中国抗生素杂志》2004年第9期542-544,575,共4页Chinese Journal of Antibiotics

基　　金：国家自然科学基金 (No:1 0 1 0 1 0 2 9)

摘　　要：利用数学模型研究抗生素作用下宿主体内带质粒与非带质粒菌群的竞争种群动力学。结果表明不合理的大剂量使用抗生素会加速细菌耐药的发展 ,滥用抗生素可能是宿主产生抗生素耐受的原因之一。为了减缓和避免抗感染治疗中的抗生素耐受 。A mathematic model was used to investigate the dynamic competitive interaction between plasmid-bearing bacteria and plasmid-free bacteria within-host under the influence of antibiotics. The results showed that antibiotic irrational use greatly increased the rate of resistance development of bacteria. So the abuse of antibiotics is perhaps one of the reasons which result in the resistance of antibiotic. Consequently, (according) to our model, a specific strategy should be applied to slow down and/or spread of antibiotic resistance during anti-infective therapy.

关 键 词：质粒 抗生素耐受 数学模型 

分 类 号：R969.3[医药卫生—药理学]