头孢唑肟与其他 5种抗生素体外抗菌活性比较(英文)  

In vitro antibacterial activity of ceftizoxime in comparison with five other agents

作　　者：肖永红[1] 刘健[1] 钟巍[1] 郝风兰[1] 杨维维[1] 

机构地区：[1]北京大学临床药理研究所,北京100083

出　　处：《中国抗生素杂志》2004年第9期556-561,共6页Chinese Journal of Antibiotics

摘　　要：目的　比较头孢唑肟与其他 5种抗生素对临床分离菌的体外抗菌活性。方法　用 NCCL S2 0 0 2年发布的琼脂平板法测定抗生素的最低抑菌浓度。结果　本研究共测定细菌 5 70株 ,其中革兰氏阴性菌 36 7株 ,革兰氏阳性菌 2 0 3株。头孢唑肟对肠杆菌科细菌与链球菌具有强大抗菌活性 ,大肠埃希氏菌、肺炎克雷伯氏菌、产气肠杆菌、志贺氏菌、奇异变形菌、摩根摩氏菌、流感噬血杆菌、肺炎链球菌、化脓链球菌、无乳链球菌、粘膜炎莫拉氏菌对头孢唑肟 10 0 %敏感。头孢唑肟对大多数肠杆菌科细菌 MIC值与头孢曲松相近 ,远低于头孢他啶和头孢呋辛。头孢唑肟对液化沙雷氏的菌抗菌活性为所有检测药物中最强的一个 ,MIC50 与 MIC90 均为0 .5 mg/ L。结论　头孢唑肟应用于临床 15年后仍保持强大抗菌活性 。Objective To compare the in vitro antibacterial activity against clinical isolates of ceftizoxime and other 5 antibiotics. Method NCCLS agar dilution method was used for the determination of (minimum) inhibitory concentrations. Results Five hundred seventy bacterial strains including 367 Gram-negative and 203 Gram-positive isolates were examined. Ceftizoxime was a potent antibiotic against Enterobacteriacaea and Streptococcus, no resistant strain was found in E.coli, K.pneumoniae, E.aerogenes, Sh.sonnei, Sh.flexneri, P.mirabilis, M.morganii, H.influenza, S.pneumoniae, S.pyogenes, S.agalactiae and (M.catarralis.) The MICs of ceftizoxime against major Enterobacteriacaea were comparable to those of ceftriaxone, and superior to those of ceftazidime and cefuroxime. S.marcescens was most susceptible to ceftizoxime in the agents tested with MIC (50) and MIC (90) of 0.5mg/L. Conclusion Ceftizoxime still kept highly antibacterial activity after 15 years clinical application in China, it can be used as empiric therapeutic agent in the treatment of moderate and severe bacterial infections.

关 键 词：头孢唑肟 头孢曲松 头孢他啶 最低抑菌浓度 体外抗菌活性 细菌 

分 类 号：R965[医药卫生—药理学]