2型糖尿病并脑梗死病人对氧磷酶基因多态性的研究  

PON1 GENE POLYMORPHISM IN NIDDM PATIENTS WITH CEREBRAL INFARCTION

作　　者：章政[1] 李江[2] 张晨[2] 

机构地区：[1]青岛大学医学院附属医院干部保健科,山东青岛266003 [2]青岛大学医学院附属医院神经内科,山东青岛266003

出　　处：《青岛大学医学院学报》2004年第4期336-337,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的　探讨对氧磷酶 (PON1 )A1 91B基因多态性与 2型糖尿病并脑梗死 (CI)的关系。②方法　应用聚合酶链式反应 (PCR)技术 ,检测 80例对照组、5 6例 2型糖尿病病人、6 0例 2型糖尿病并CI病人PON1A1 91B基因型及基因频率。③结果　 2型糖尿病组与对照组相比 ,PON1A1 91B基因型频率、等位基因频率无显著差异(χ2 =1 .4 2、1 .4 5 ,P >0 .0 5 )。 2型糖尿病并CI组与 2型糖尿病组、对照组相比 ,PON1 1 91B基因型频率显著增高(χ2 =4 .1 5 2、6 .1 4 1 ,P <0 .0 5 ) ,等位基因频率显著增高 (χ2 =9.5 4 5、8.32 9,P <0 .0 5 )。④结论　糖尿病并CI病人B基因突变可能是其发病的危险因素之一。Objective To explore the relationship between the PON1 A191B gene polymorphism and NIDDM with cerebral infarction(CI). Methods PON1 A191B genotypes were detected in 80 healthy controls, 56 patients with NIDDM and 60 NIDDM with CI by polymerase chain reaction(PCR). Results No significant differences in PON1 A191B gene frequency between the NIDDM patients without CI and healthy controls( χ 2=1.42,1.45;P >0.05). The frequencies of B genotype and the B allele frequency increased significantly in the NIDDM patients with CI ( χ 2=4.152-9.545,P <0.05). Conclusion B genotype mutation may be one of the risk factors of cerebral infarction in NIDDM patients.

关 键 词：糖尿病 非胰岛素依赖型 脑梗死 对氧磷酶基因 基因型 基因频率 

分 类 号：R587.1[医药卫生—内分泌] R743.3[医药卫生—内科学]