一种新型葡萄糖基化竹红菌素的合成和ESR研究  

Synthesis and ESR Investigation of a New Hypocrellin Glycoside

作　　者：夏盛钦[1] 陈景荣[1] 王雪松[1] 张宝文[1] 

机构地区：[1]中国科学院理化技术研究所,北京100101

出　　处：《感光科学与光化学》2004年第5期363-369,共7页Photographic Science and Photochemistry

基　　金：国家自然科学基金项目(20272065).

摘　　要：以巯基乙酸取代的竹红菌乙素和氨基葡萄糖为反应物,只用一步就合成了一种新型葡萄糖修饰的竹红菌乙素.氨基葡萄糖的取代改善了竹红菌乙素的水溶性及其在光疗窗口的吸收,并保持了其产生1O2、O2·-、·OH和半醌负离子自由基的光化学活性.A new glycose derivatized hypocrellin B was synthesized in a facile way.The water-solubility and the absorbance in the phototherapeutic window was enhanced in the resulting product over hypocrellin B.Electron spin resonance (ESR) measurements indicated that this glycoside remained the photodynamic capability of generating ~1O_2,O_2^(·-),~·OH, and semiquinone anion radical.

关 键 词：竹红菌乙素 氨基葡萄糖 水溶性 活性氧 

分 类 号：O629[理学—有机化学]