左氧氟沙星经纤维支气管镜介入治疗耐多药空洞型肺结核近期疗效观察  

Effect of levoflosacin by bronchofiberscope and catheter intervention in therapy on patients with multi-drug resistant pulmonary tuberculosis

作　　者：张国庆[1] 

机构地区：[1]新乡医学院第一附属医院结核内科,河南卫辉453100

出　　处：《临床荟萃》2004年第20期1152-1153,共2页Clinical Focus

摘　　要：目的　观察经纤维支气管镜 (纤支镜 )注药介入治疗耐多药空洞型肺结核 (MDR TB)的近期疗效。方法　 75例MDR TB患者随机分为治疗组 4 5例和对照组 30例 ,两组共同应用异烟肼 (H)、利福喷丁 (L)、丙硫异烟胺(Th)、乙胺丁醇 (E)和丁胺卡那霉素 (A) ,左氧氟沙星 (V) ,治疗组另加用左氧氟沙星经纤支镜介入治疗 ,比较两组的临床疗效。结果　治疗 6个月痰菌阴转率、空洞闭合率、病变吸收率治疗组分别为 82 %、78%、86 % ,对照组分别为5 0 %、4 3%、5 7% ,两组比较差异有统计学意义 (P <0 .0 1)。Objective To study the short-term efficacy of levoflosacin by bronchofiberscope and catheter intervention in therapy on patients with multi-drug resistant pulmonary tuberculosis(MDR-TB). Methods Seventy-five cases of MDR-TB patients were randomly divided into the treatment group (45 cases) and the control group(30 cases). Both groups received the therapy of isoniazid(H), rifapentine(L), prothionamicle(Th), ethambutol(E), amikacin(A), and levoflosacin(V),while the treatment group also received the theapy of cevoflosacin by bronchofiberscope and catheter intervention. Comparisons were made between the two groups in curative effects. Results Afler 6 months’ treatment, sputum bacteria negative-transformation, cavity closing and focus absorbance were 82%,78%,and 86%, respectively in the treatment group,while those were 50%,43%,and 57%, respectively in the control group. There was significant difference between the two groups(P< 0.01). Conclusion Levofloxacin by bronchofiberscope with other chemotherapy drugs shows obvious efficacy for MDRP-TB patients with cavities.

关 键 词：结核 肺 左氧氟沙星 纤维支气管镜 导管插入术 

分 类 号：R521[医药卫生—内科学]