IFN和PDS合剂体内抗流感病毒的作用  

The Effect of IFN-PDS against Influenza Virusin vivo

作　　者：程晓耕[1] 赵雪俭[2] 迟宝琦[1] 曹杰[2] 张淑洁[1] 王晓宇[1] 王成[1] 朱燕[1] 

机构地区：[1]长春生物制品研究所,吉林长春130062 [2]吉林大学基础医学院,吉林长春130021

出　　处：《微生物学杂志》2004年第5期64-65,共2页Journal of Microbiology

基　　金：吉林省科技发展重点项目 (No .2 0 0 3 0 5 0 1)

摘　　要：观察了IFN与PDS合剂的体内抗病毒效果。首先排除IFN和PDS对动物的毒性作用 ,再以不同剂量的单剂和合剂给小鼠用药。用流感强毒株对小鼠进行攻击 ,同时以利巴韦林和正常小鼠作为对照。通过对动物死亡率、肺部病变的病理组织学检查结果进行比较 ,合剂组效果明显好于单剂组 ,且有剂量效应关系。上述结果表明 ,IFN和PDS合剂可明显减轻流感病毒感染过程中的肺组织病变 ,可用于流行性感冒的治疗。Antiviral effect in vivo of the compound of IFN and PDS was observed in this study. At first the toxicity of IFN-PDS compound to mice was excluded and then the animals were administrated with different doses of IFN, PDS and PDS-IFN compound, respectively. The strong virulent strain of influenza virus was applied to attack the mice, and in the meantime the ribavirin-taken mice and normal mice were used as the controls. Compare to the mortality and the lesions in lung by histopathological examination among the different animal groups, the mice that given with PDS-IFN compound showed higher antiviral effect with dose-dependent pattern than the other groups. The results of this study indicate that PDS-IFN compound can significantly decrease lung lesions during influenza virus infection and this compound can be used as an efficient drug to cure influenza.;

关 键 词：流感病毒 干扰素 人参二醇皂甙 

分 类 号：R373.13[医药卫生—病原生物学]