壳聚糖/海藻酸钠微囊作为口服控释制剂载体的研究  

Study on Chitosan/Alginate Microcapsules as Orally Controlled Release Vector

作　　者：石晓丽[1] 徐军[1] 

机构地区：[1]长春生物制品研究所,吉林长春130062

出　　处：《微生物学杂志》2004年第5期113-114,共2页Journal of Microbiology

摘　　要：壳聚糖与海藻酸钠通过聚电解质络合反应制备成壳聚糖 /海藻酸钠微囊 ,其粒径为 1mm左右。以干扰素为模型药物 ,其包封率达 90 %以上。同时还研究了在不同 pH条件下 ,干扰素的控制释放情况。结果表明 :微囊在模拟胃液 (pH 1.0 )中 3h的药物释率仅为≤ 5 % ,但在模拟肠液 (pH 7.4 )中 3h ,80 %～ 90 %的药物被释放。Chitosan/alginate microcapsules were prepared through chitosan reacted with sodium alginate under the presence of calcium chloride to form microcapsules with a polyelectrolyte complex membrane. The microcapsules had a diameter of approximate 1 mm. When using IFN as a modal drug, the encapsulation efficiency was high than 90%. The controlled release status of IFN was investigated at the different pH values. The result showed that the proportion of the released modal drug from the microcapsules in mimic gastric solution (pH 1.0) for 3 h was less than 5%, but that in mimic intestinal solution (pH 7.4) for 3 h was as high as 80%～90%.;

关 键 词：壳聚糖/海藻酸钠微囊 干扰素 包封率 控制释放 

分 类 号：R944[医药卫生—药剂学]