中药中α-糖苷酶抑制剂的筛选(英文)  

SCREENING α-GLUCOSIDASE INHIBITORS IN TRADITIONAL CHINESE MEDICINES

作　　者：白钢[1] 王冬莉[1] 曹学琳[1] 肖会姣[1] 耿鹏[1] 刘茜[1] 杨文博[1] 

机构地区：[1]南开大学生命科学学院微生物学系,天津300071

出　　处：《南开大学学报（自然科学版）》2004年第3期98-102,共5页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：SupportedbyScienceFoundationofTianjin(023803811)863ProjectofModernizationofTraditionalChineseMedicine

摘　　要：本文通过在α-糖苷酶水解麦芽糖的体系中加入一定量的中药提取物,并采用葡萄糖氧化酶法测定葡萄糖的释放量,建立了一个中药中α-糖苷酶抑制剂的筛选模型.应用该模型对糖尿病治疗中药的筛选结果表明,桑白皮、桑枝以及桑叶等十种中药被证实有α-糖苷酶的抑制剂活性,可以有效地抑制或延缓淀粉和麦芽糖水解为葡萄糖,揭示了中药降糖的另一种机理,并为开发安全有效的糖尿病治疗中药提供了新的思路.In this paper, the sensitive screening model of α-glucosidase inhibitor was established. The results showed that Cortex Mori, Ramulus Mori and Folium Mori among ten traditional Chinese medicine (TCM) extracts had strongly α-glucosidase inhibition in hydrolysis processes of starch or maltose. Therefore , TCM extracts might cure diabetes. The present researches remain to be developed the new natural medicines for safe and effective diabetic therapy.

关 键 词：α—糖苷酶抑制剂 糖尿病 中药 桑白皮 桑枝 桑叶 

分 类 号：Q819[生物学—生物工程]