喉癌患者未被癌组织侵蚀的喉内肌组织学变化分析  

The analysis of histological changes of the uninva sioned intrinsic laryngeal muscles of laryngeal carcinoma patients

作　　者：李君[1] 杨式麟[1] 

机构地区：[1]中国医科大学附属第二医院耳鼻咽喉科,辽宁沈阳110004

出　　处：《中国医科大学学报》2004年第5期411-413,共3页Journal of China Medical University

摘　　要：目的 :探讨喉癌患者未被癌组织侵蚀的喉内肌肌纤维形态结构的变化 ,为科研工作选择对比材料提供依据。方法 :3例正常成人和 5例喉癌患者病变对侧或与之不同分区的甲杓肌、环杓侧肌及环杓后肌 (肉眼及镜下均未见癌组织侵蚀 ,喉返神经亦未受侵蚀 )制成切片 ,HE染色 ,光镜下观察肌纤维的形态 ;应用显微图像分析仪测量肌纤维的横截面积、最大宽度和数量。结果 :与正常成人相比 ,喉癌患者各喉内肌肌纤维形态变化较大 ;肌纤维横截面积、最大宽度显著增加 (P <0 .0 1) ,增加的幅度以环杓后肌为最大 ;肌纤维数量两组无差异。结论 :肌纤维横截面积和最大宽度是反映肌肉功能状态的较为可靠的指标。在进行科学实验时 。Objective: To investigate the histological c hanges of the uninvasioned intrinsic laryngeal muscles(ILM)of patients with lary ngeal carcinoma and control group.Methods: The ILMs were take n from total laryngectomy specimens with carcinoma(5 cases) and from autopsy (3 cases) .In all cases the selected ILMs were clinically and histologically norma l in appearance.With HE staining and photo-micrograph, morphologic indexes of muscle fiber were studied, such as fiber shape, cross-sectional fiber area, max imum width and number.Results: Compared with the normal speci mens, a marked difference in the ILMs appearance of laryngeal carcinoma patients was found.The cross-sectional fiber area and the maximum fiber width increase d significantly in patients' muscles (P<0.01).No difference was found in n umber of muscle fiber (P>05). Conclusion: Cross-sectio nal fiber area and maximum fiber width are reliable indexes for muscle function compared with number of muscle fibers.In experiments, the muscles uninvasioned by carcinoma in patients can't be used as normal control

关 键 词：喉癌 喉内肌 肌纤维 HE染色 

分 类 号：R329.4[医药卫生—人体解剖和组织胚胎学]