心肌细胞团搏动整数倍节律的非线性动力学机制  

NONLINEAR DYNAMIC MECHANISMS OF THE INTEGER MULTIPLE RHYTHMS GENERATED BY CARDIAC MYOCYTES

作　　者：刘志强[1] 古华光 杨明浩[1] 李莉[1] 刘红菊[1] 范少光[2] 任维[1] 

机构地区：[1]航天医学工程研究所 [2]北京大学医学部生理学系

出　　处：《生物物理学报》2004年第5期363-370,共8页Acta Biophysica Sinica

基　　金：总装备部试验技术重点项目(01103302)

摘　　要：利用心肌细胞耦合模型研究心肌整数倍节律的动力学机理。确定性模型仿真揭示了心肌细胞团同步搏动加周期分岔的节律变化规律;随机模型仿真发现在加周期分岔序列中分岔点附近会出现整数倍节律,其中,0-1整数倍节律产生于从静息到周期1的Hopf分岔点附近,1-2整数倍节律产生于周期1和周期2极限环间的加周期分岔点附近;对系统相空间轨道的分析进一步揭示出整数倍节律是由系统运动在相邻的两个轨道之间随机跃迁形成的。上述分析结果不仅阐明了心肌整数倍节律的机理,并且揭示了各种整数倍节律与加周期分岔序列中相邻节律的内在联系,为重新认识心律变化的规律开辟了新的途径。Coupled models of cardiac myocytes were used to investigate the mechanisms of integer multiple rhythms discovered experimentally. Simulation in the deterministic model elucidated a rhythm transition process governed by a period adding bifurcation scenario. Simulation using the stochastic model further revealed that integer multiple rhythms occurred near each of the bifurcation points in the bifurcation scenario. The 0-1 integer multiple rhythm appeared near the Hopf bifurcation point, while the 1-2 integer multiple rhythm appeared near the period adding bifurcation point between two limit cycles. The analysis of the phase space trajectories clearly elucidated that the integer multiple rhythms were formed by a stochastic alternating of the system between two neighbouring orbits. Such theoretical analysis not only revealed the dynamic mechanism of the integer multiple rhythms, but also elucidated the relations of the integer multiple rhythms with other rhythm patterns within the context of a period adding bifurcation scenario. Our experimental and theoretical works created a new way for the study of the principles of the cardiac rhythm transitions.

关 键 词：心肌细胞团 整数倍节律 Chay模型 耦合 加周期分岔 

分 类 号：R331.38[医药卫生—人体生理学]