强酸性离子交换膜催化合成二氢嘧啶酮药物中间体  

Catalytic synthesis of 5-methoxycarbonyl-4-(4-methoxyphenyl)-6- methyl-3,4-dihydropyrimidine-2(1H)-one by strong acidic ion-exchange membrane

作　　者：李治[1] 倪淑晶[1] 施婷婷[1] 

机构地区：[1]华东理工大学化学与制药学院,上海200237

出　　处：《应用化工》2004年第5期36-37,50,共3页Applied Chemical Industry

摘　　要：在HF 101强酸性离子交换膜的存在下,由对羟基苯甲醛、乙酰乙酸甲酯与脲一步合成了5 甲氧羰基 4 (4 甲氧苯基) 6 甲基 3,4 二氢嘧啶 2(1H) 酮。当对羟基苯甲醛、乙酰乙酸甲酯与脲的摩尔比为1∶2∶5,乙醇作溶剂,3g离子交换膜,回流2h,产物收率达95.4%。同时研究了离子交换膜作为催化剂的重复使用情况。5-methoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-one was synthesized from anisaldehyde, methyl acetoactate and urea in presence of HF-101 strong acidic ion-exchange membrane.The yield of the 3,4-dihydropyrimidine-2(1H)-one was up to 95.4% under mole ratio of anisaldehyde, methyl acetoactate and urea is 1∶2∶5, ion-exchange membrane is 3 g,ethyl alcohol as solvent and refluxing for 2 h.The reusability of the catalyst was studied.

关 键 词：强酸型离子交换膜 催化 药物中间体 5-甲氧羰基-4-(4.甲氧苯基)-6-甲基-3 4-二氢嘧啶-2(1H)-酮 

分 类 号：TQ254.1[化学工程—有机化工]