银屑胶囊对急性血瘀模型大鼠血液流变学的影响  

Effect of Yin-xie capsule on hemorbeological parameters in acute blood stasis model rats

作　　者：宋少刚[1] 陈振德[1] 李艳[2] 陶金成[1] 田洁[1] 

机构地区：[1]深圳市第二人民医院药剂科,广东深圳518035 [2]商洛市中心医院药剂科,陕西商洛726000

出　　处：《广东药学》2003年第6期30-32,共3页Guangdong Pharmaceutical Journal

摘　　要：目的 从血液流变学角度研究银屑胶囊治疗银屑病的药理作用。方法 采用注射肾上腺素——冰水浴法制作大鼠急性血瘀模型,观察对血液流变学指标的影响。结果 银屑胶囊1.8 g/kg及0.6g/kg灌胃,连续给药13d,均可使急性血瘀模型大鼠的全血高切粘度、全血低切粘度、全血高切还原粘度及血浆粘度显著减小。结论 银屑胶囊可降低急性血瘀模型大鼠的全血高切粘度、全血低切粘度、全血高切还原粘度及血浆粘度,改善血液流变性,有活血化瘀作用。Objective To observe effect of Yin-xie capsule on hemorheological parameters in acute blood stasis model rats. Methods Adr was administered to SD rats by subcutaneous,and immersed in icy water,observed the changes of hemorbeological parameters. Results Yin-xie capsule(0. 6,1. 8 g · kg-1 ,ig) could significantly decrease the whole blood HSV.the whole blood LSV.the whole blood high shear reduced viscosity and the blood plasma viscosity. These results suggest that Yin-Xie capsule can activate blood circulation and remove blood stasis. Yin-xie capsule (0.6,1. 8 g · kg-1 ,ig)could significantly decrease the whole blood HSV,the whole blood LSV, the whole blood high shear reduced viscosity and the blood plasma viscosity. Conclusion Yin-xie capsule can activate blood circulation and remove blood stasis.

关 键 词：银屑胶囊/药学 银屑病 血液流变学 

分 类 号：R285[医药卫生—中药学]