细胞因子和骨代谢指标与老年男性骨质疏松症的关系  

Relationship of cvtokines and bone metabolic markers to osteoporosis in aged males

作　　者：罗南萍[1] 胡成进[1] 李金花[2] 陈英剑[1] 王瑞山[1] 尹秋霞[1] 

机构地区：[1]济南军区总医院实验诊断科,250031 [2]济南军区总医院骨矿检测中心,250031

出　　处：《中华核医学杂志》2003年第6期361-362,共2页Chinese Journal of Nuclear Medicine

摘　　要：目的 探讨细胞因子与骨代谢生化指标在老年男性骨质疏松症发病机理中的作用及相互关系。方法 采用放射免疫分析法和生化速率法检测90例老年男性骨量减少和骨质疏松患者血清白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、骨钙素(BGP)、睾酮(T)、血清碱性磷酸酶(AKP)、血清钙(Ca)的水平,同时行骨密度检测,检测结果与青中年和老年健康人比较。结果 老年男性患者IL-4、IL-6水平随病情加重而增高,与不同年龄对照组比较差异有显著性(P<0.05,P<0.01);IL-10、BGP、AKP、T表达则不同程度降低,均与青中年对照组差异有显著性(P<0.05)。两组患者骨密度值均低于青中年对照组,差异有显著性(P<0.01),而老年骨质疏松组骨密度低于骨量减少组(P<0.05)。结论 老年男性在从骨量减少到骨质疏松的病理过程中,骨转化呈骨吸收增加、骨形成减少的变化规律。IL-4、IL-6、IL-10与其他骨代谢生化指标可辅助诊断骨质疏松症。Objective To observe the relationship of cytokines and bone metabolic markers to osteoporosis in aged men. Methods Serum interleukin-4 (IL-4), IL-6, IL-l0, bone glaprotein (BGP), testosterone (T), alkaline phosphatase (AKP), Ca and bone density of aged men with osteoporosis or bone mass loss were assessed and compared with those of middle-aged and aged healthy men. Results The levels of serum IL-4 and IL-6 increased with severity of osteoporosis and the differences were significant compared with normal controls ( P < 0.05, P < 0.01) . The levels of IL-10, BGP, AKP and T decreased at different degrees and also had significant differences compared with normal controls ( P < 0.05) . Bone density of aged men with osteoporosis and bone mass loss was lower than that of middle-aged healthy men ( P < 0.01), and bone density of aged men with osteoporosis was apparently lower than that of men with bone mass loss (P < 0.05). Conclusions From bone mass loss to osteoporosis, the deteriorating process presents as bone absorption increasing and osteogenesis decreasing. IL-4, IL-6 and IL-10 and other bone metabolic markers may play a role in diagnosis of osteoporosis.

关 键 词：老年人 男性 骨质疏松症 病理学 放射免疫分析法 生化速率法 白细胞介素4 骨钙素 睾酮 碱性磷酸酶 

分 类 号：R58[医药卫生—内分泌]