赛庚啶对大鼠垂体-性腺轴功能的影响  

Effects of cyproheptadine on function of pituitary-sexual gland axis in rats

作　　者：康白[1] 胡庆伟[1] 李广宙[2] 李正斌[1] 高尔[1] 

机构地区：[1]潍坊医学院药理学教研室,山东潍坊261042 [2]潍坊医学院附院核医学科,山东潍坊261031

出　　处：《中国现代应用药学》2003年第6期458-460,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的　研究赛庚啶对大鼠垂体 性腺轴内分泌功能的影响。方法　用放射免疫分析法 (RIA)和电镜 ,观察赛庚啶对大鼠垂体 性腺轴内分泌功能及垂体促性腺细胞、卵巢、睾丸细胞超微结构的影响。结果　赛庚啶 2 .3mg·kg-1·d-1,ig ,连续用药14d ,可明显降低雌性大鼠血清卵泡刺激素 (FSH)、孕酮 (P)的含量 (P <0 .0 1) ,而升高黄体生成素 (LH)的水平 (P <0 .0 5 )。 4 .6mg·kg-1·d-1赛庚啶不但可引起雌性大鼠血清FSH、雌二醇 (E2 )、P的水平显著降低 ,升高LH的含量 (P <0 .0 5及 <0 .0 1) ,而且使雄性大鼠血清LH、T的含量明显升高 (P <0 .0 5 )。组织形态电镜观察 ,该药亦可引起大鼠卵巢细胞超微结构的退行性改变 ,睾丸支持细胞呈分泌状态 ,而垂体促性腺分泌细胞则无明显变化。结论　赛庚啶可抑制雌性大鼠FSH、E2 、P的分泌 ,促进雌、雄大鼠LH及雄性大鼠T的分泌 ,其机制可能与赛庚啶直接影响靶器官的分泌细胞有关。OBJECTIVE To study the influence of cyproheptadine(CYP) on the endocrine function of pituitary sexual gland axis in rats. METHOD The effect of CYP on function of pituitary sexual gland axis and ultramicrostructure of gonadotrophin cells, testicle and ovary cells in rats was observed by radioimmunoassay (RIA) and electron microscope.RESULTS It was found that CYP 2.3mg×kg -1 ×d -1 ,ig for 14d decreased serum FSH and P concentration and increased serum LH concentration in female rats significantly( P <0.01 and 0.05). After given CYP 4.6mg×kg -1 ×d -1 , serum FSH?E 2 and P level were remarkably decreased and serum LH level was increased in female rats ( P <0.01). Moreover, the serum LH and T concentration were increased in male rats( P <0.05). The retrograde change of ultramicrostructure of ovary cells in female rats and secretion change of ultramicrostructure of testicle cells in male rats, but the unchangedness of gonadotrophin cells ultramicrostructure in rats were observed.CONCLUSION CYP inhibited the secretion of FSH?P?E 2 in female rats and increased the secretion of LH in female and male rats; The secretion of T was increased in male rats. The mechanism may be that CYP influence the secretion cells of target organ directly.

关 键 词：赛庚啶 垂体-性腺轴 超微结构 

分 类 号：R976[医药卫生—药品]