金尔伦治疗重型颅脑创伤的临床观察  

Clinical Study of Naloxone in Treatment of Severe Brain Injury

作　　者：王向阳[1] 肖剑[1] 武金有[1] 

机构地区：[1]长治医学院附属和济医院神经外科,046000

出　　处：《长治医学院学报》2003年第4期263-265,共3页Journal of Changzhi Medical College

摘　　要：目的 :探讨应用金尔伦 (盐酸纳洛酮 )治疗重型颅脑创伤的临床疗效。方法 :72例重型颅脑创伤患者 (GCS 3分～ 8分 )随机分为金尔伦治疗组和对照组。观察治疗 1W后生命体征、颅内压、意识觉醒、GCS评分变化和 3个月后GOS评分。结果 :金尔伦组 1W后呼吸循环较快恢复稳定 ,颅内压显著升高者明显少于对照组 ,意识清醒率及GCS升高幅度明显高于对照组 (P <0 .0 5 )。金尔伦组伤后 3个月恢复良好率显著高于对照组 ,重残率明显减少 (P <0 .0 5 )。结论 :金尔伦能拮抗颅脑创伤后内源性阿片肽引起的应激性反应 ,缩短昏迷时间 ,降低伤残率 ,促进神经功能恢复 ,改善预后。Objective:To assess clinical effects of Naloxone(NLX) in treatment of severe brain injury.Methods:70 patients(GCS3～8)were randomly assigned into two groups(36 cases were treated with NLX and 36 cases were control).The vital signs,intracranial pressure(ICP),consciousness,GCS and clinical feature of two groups were observed.Results:The fluctuation of vital signs in the first weed was smoother in NLX group,and the increase of ICP was less remarkable than that in control(P<0.05).More patients revived in NLX group than that in control accompanied by higher recovery rate and lower disability after three month(P<0.05).Cnoclusions:As a specifictity opioid antagonist,NLX can relieve traumatic brain edema and ICP,improve the recovery of coma and reduce the disability in severe brain injury.

关 键 词：纳洛酮 颅脑创伤 阿片肽 

分 类 号：R651.15[医药卫生—外科学]