实验性脑弥漫性轴索损伤的磁共振波谱研究  

Magnetic resonance spectroscopy of experimental diffuse axonal injury

作　　者：胡春洪[1] 生晶[1] 丁乙[1] 陈剑华[1] 

机构地区：[1]苏州大学附属第一医院影像中心,215006

出　　处：《江苏医药》2004年第7期489-491,i001,共4页Jiangsu Medical Journal

基　　金：江苏省医学重点人才基金 (RC 2 0 0 3 0 96)

摘　　要：目的　建立SD大鼠脑弥漫性轴索损伤 (DAI)模型 ,探讨磁共振波谱 (MRS)对DAI的早期诊断价值及前景。方法　雄性SD大鼠 2 0只 ,自由落体法复制弥漫性脑轴索损伤动物模型 ,分别于损伤前及损伤后 4h、8h、2 4h、4 8h行MRS检查 ,观察NAA/Cr、Cho/Cr的变化 ,并与病理对照。结果　打击后 2 4h即可见轴索损伤的病理表现 ;MRS示轴索损伤后NAA/Cr 4h显著下降 ;8h起逐渐恢复上升 ,但 4 8h又明显下降 ;而Cho/Cr变化无显著差异。结论　DAI急性期可能存在短暂可恢复的时间窗。MRS有望为DAI的早期诊断。Objective To set up a model of diffuse axonal injury(DAI) in SD rats and to assess the value and prospect of magnetic resonance spectroscopy(MRS)in early diagnosis of DAI.Methods DAI model was established in 20 male SD rats utilizing a weigh-drop device,and MRS was performed before trauma and after trauma for 4,8,24,48 hours.The ratio of N-acetylaspartate/creatine(NAA/Cr)and choline/creatine (Cho/Cr)were calculated and correlated with pathological findings respectively.Results Axonal changes were confirmed in microscopic study 24 hours after injury.The ratio of NAA/Cr decreased drastically at 4 hours after trauma,followed by a steadily recover at 8 hour,and decline again at 48 hour,though the ratio of Cho/Cr had no significant change.Conclusion There may be a reversible narrow time-window in acute phase of DAI.MRS would play a positive role in early diagnosis,prognosis and follow-up of DAI.

关 键 词：实验性 脑弥漫性轴索损伤 磁共振波谱 DAI MR检查 

分 类 号：R651.15[医药卫生—外科学]