Ⅱ型糖尿病病人红细胞胰岛素受体和膜流动性的观察  

Observations of Erythrocyte Insulin Receptor and Membrane Fluidity of Erythrocyte in Type Ⅱ Diabetics

作　　者：吴国亭[1] 张巾超[1] 于云霞[1] 刘宪冬[1] 刘丽娜[1] 李孟兰[1] 王秀芝[1] 李晖[2] 马丽英[2] 张淑华 施守勤 赵鸿璐 

机构地区：[1]哈尔滨医科大学二院内分泌科 [2]哈尔滨医科大学病理生学理教研室 [3]哈尔滨铁路中心医院

出　　处：《哈尔滨医科大学学报》1993年第1期54-56,共3页Journal of Harbin Medical University

摘　　要：本文采用配对分析,测定了30例Ⅱ型糖尿病(NIDDM)和30名正常人的红细胞胰岛素受体和红细胞膜流动性。发现NIDDM红细胞胰岛素受体位点减少,而红细胞膜流动性显著降低,二变量间呈有意义的负相关。细胞膜流动性的下降可能是NIDDM胰岛素受体或受体后缺陷的原因之一。Thirty patients with NIDDM and thirty normal subjects were included in a paired study for determination of erythrocyte insulin receptor and membrane fluidity of erythrocyte. The results showed that receptor numbers decreased in NIDDM patients and membrane fluidity obviously reduced compared with the control group, a significant negative correlation was found between the two parameters and decreased membrane fluidity might be one of the causes leading to insulin receptor or postreceptor defects in NIDDM

关 键 词：糖尿病 胰岛素 受体 膜流动性 

分 类 号：R587.102[医药卫生—内分泌]