革兰氏阴性条件致病菌的药敏及R质粒的检测  

Detection of Drug Sensitivity and Conjugative R Plasmid for Gram-Negative Opportunistic Bacteria

作　　者：韩淑兰[1] 赵月辉[1] 杨晓菲[1] 程厚本 崔玉娥[1] 陈会[2] 郭薇媛[2] 郭俊仿 

机构地区：[1]哈尔滨医科大学微生物学教研室 [2]哈尔滨医科大学二院细菌室

出　　处：《哈尔滨医科大学学报》1993年第1期37-39,共3页Journal of Harbin Medical University

摘　　要：本文检测了41株革兰氏阴性条件致病菌的药敏和R质粒。结果表明,耐3种以上抗生素的菌株达97.6%,而只耐2种抗生素的菌株仅占2.4%;41株均耐氨基苄青霉素;其中16株检出R质粒占,39%。通过耐药谱与转移的耐药基因分析表明,耐药性基因虽不完全由R质粒携带,但R质粒转移是细茵获得耐药性的主要机制之一。This paper describes detection of drug sensitivity and conjugative R plasmid for 41 strains gram-negative opportunistic bacteria . It was found that the drug resistance was serious, 97.6% of those strains resisted to 3 agents or more, and conjugative R plasmid were detected in 16 strains, occupying 39% of all detected strains. The analysis of antibiograms and conjugative R plasmid revealed that: it is not all gene of drug resistance on conjugative plasmid, but R plasmid transfer is one of mechanisms for drug resistance acquired by bacteria.

关 键 词：致病菌 革兰氏 阴性杆菌 R质粒 

分 类 号：R446.5[医药卫生—诊断学]