肺炎支原体感染和哮喘患儿血清IL-4和总IgE水平的研究  

Research of IL-4 and total IgE in mycoplasma pneumoniae infected and bronchial asthma attacking children patients

作　　者：毛海英[1] 曹兰芳[1] 马敏[1] 

机构地区：[1]上海第二医科大学仁济医院儿科,上海200001

出　　处：《上海第二医科大学学报》2004年第8期653-654,共2页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：上海市科委基金资助项目(004119050).

摘　　要：目的 探讨肺炎支原体感染与支气管哮喘的相关性。方法 采用酶联免疫方法对60例肺炎支原体感染患儿,60例支气管哮喘患儿进行血清白细胞介素4(IL-4)及总IgE水平的测定,以30例正常者作为对照组。结果 肺炎支原体感染、支气管哮喘组血清IL-4和总IgE水平较正常对照组明显升高(P<0.01),支气管哮喘组又较肺炎支原体感染组显著升高(P<0.05)。结论 肺炎支原体感染与支气管哮喘在发病机制方面存在一定的相关性。Objective This study was undertaken to discuss the relevance of mycoplasma pneumoniae infection and bronchial asthma. Methods We detected the IL-4 and the total IgE in 60 mycoplasma pneumoniae patients 60 bronchial asthma and 30 controls. Results The IL-4 and the total IgE of mycoplasma pneumoniae and bronchial asthma was significantly elevated compared to controls ( P<0.01); the level in the bronchial asthma patients was higher than mycoplasma pneumoniae infection group (P<0.05). Conclusion We found that there is some corre-lation between the pathogenesis of mycoplasma pneumoniae and bronchial asthma.

关 键 词：肺炎 支原体感染 哮喘 血清IL-4 IGE 白细胞介素4 

分 类 号：R725.6[医药卫生—儿科]