活血生肌法抗瘢痕作用机理的实验与临床研究  

The Study of Promoting Blood Circulation and Granulation Treatment on Restraining Scar Formation

作　　者：周春英 周东 孙龙 孙凤兰 杜玉凤 王华军 

机构地区：[1]青岛市海慈医疗集团中医医院,266033

出　　处：《青岛医药卫生》2004年第2期82-86,共5页Qingdao Medical Journal

摘　　要：目的　探讨活血生肌法抗瘢痕的作用机理与疗效。方法　动物实验用大鼠造模后随机分为三组 :治疗Ⅰ组、治疗Ⅱ组、对照组。分别给予半导体激光照射、活血生肌疗法 (生肌活血油 +半导体激光照射 )、碘伏纱布处理。取创面肉芽组织及其血液 ,测定纤维连接蛋白 (Fn)及创面碱性成纤维因子 (b FGF)的含量 ,同时观察伤口愈合情况 ,进行比较。临床研究 :以76例腋臭术后切口为抗瘢痕研究对象 ,分为A、B、C三组 (A组对照组、B组治疗Ⅰ组、C组治疗Ⅱ组 )。三组除常规用药外 ,B组与C组再分别给予半导体激光照射及活血生肌疗法 (生肌活血油 +半导体激光照射 )治疗。结果　动物实验表明 ,治疗Ⅱ组可明显提高血液及肉芽组织中Fn的含量 ;在创面修复的炎症和增殖期b FGF水平可显著增加 ,在塑形期b FGF水平降低 ;改善创面血液循环 ,促进中性粒细胞浸润和巨噬细胞的游出 ,提高局部抗感染能力 ;加速新陈代谢 ,与治疗Ⅰ组、对照组相比具有显著性差异。C组在切口周围肿胀程度、疼痛缓解时间、愈合时间、切口愈合瘢痕宽度、病人满意程度等指标方面明显优于A、B组。结论　活血生肌疗法具有消肿胀、生新肌、通血脉。Objects To study the inhibiting effects of promoting blood circulation and granulation treatment on scar formation.Methods SD rats were divided into 3 groups with Chinese medicine ointment for promoting blood circulation and regenerating tissue along with semiconductor laser,or with semicon ductor laser,with tincture of iodine as control,respectively.the level of Fn and b-FGF were measured in wound tissue specimen and blood,the healing of wounds were observed.comparisons were also made between the patients with axillary osmidrosis after surgical excision in terms of wound healing and scar formation.Results The level of Fn were higher than those in control.the level of b-FGF increased at the stage of inflammation whereas decreased at the recovery stage.urthermore,the releasing of macrophages and migrating of neutrophil were promoted and the ability of avoiding infection was improved.Conclusion The results suggest that promoting blood circulation and granulation treatment has the effects of relieving swelling,regenerating tissue,removing stasis,and reducing scar and appears to be affective for restraining scar and improving healing quality.this method is satisfied by the patients and worthy to be applied.

关 键 词：活血生肌法 瘢痕 实验 治疗 半导体激光照射 碘伏纱布 

分 类 号：R269.196[医药卫生—中西医结合]