米索前列醇用于足月引产100例临床观察  

Clinical Study of Misoprostol for Induced Labor of Term Pregnancy

作　　者：孙彩芹[1] 李建霞[1] 黎鲜[1] 

机构地区：[1]山东省青岛市第八人民医院,261000

出　　处：《实用全科医学》2004年第6期536-537,共2页Applied Journal Of General Practice

摘　　要：目的　探讨米索前列醇用于足月妊娠引产的可行性及对母儿的安全性。方法　对 1 0 0例足月妊娠单胎头位初产妇阴道后穹窿置米索前列醇 2 5ug,观察宫缩情况 ,若无规律性宫缩则每 4小时重复置药 ,直至出现规律性宫缩 ,总量不超过 1 50ug;与 1 0 0例同样条件的孕妇用催产素引产对照。结果　米索组引产成功率分别为 78%明显高于对照的 61 % (P <0 .0 1 )。米索组临产发动时间及总产程均显著短于催产素组 (P <0 .0 1 ) ,剖宫产率 1 9.2 3 %显著低于对照组 36 .0 7% (P <0 .0 5)。结论　米索前列醇用于足月妊娠引产安全、有效 ,能降低剖宫产率 ,有利于计划分娩。Objective To study the efficiency and safety of misoprostol placed in the posterior fornix of vagina for induced labor of term pregnancy. Methods Misoprostol was placed in the posterior fornix of vagina in misoprwstol group (100 primiparae were term pregnancy and single birth, the fetus were cephalic presentation). Misoprostol was given every 4 hours until the regular uterine contraction appeared. The total dosage was less than 150 μg a day. Another 100 primiparae (with the same conditions) treated with oxytocin intravenously as controls. Results The success ratio of induced labor in misoprostol group (78%) was higher than it in control group (61%) (P<0.01). The average time to labor and total stage of labor in misoprostol group was significantly shorter than that in control group (P<0.01). The cesarean section rate in misoprostol group was lower than that in control group (P<0.05). Conclusions Lower dosage misoprostol is safe and effective for induced labor of term pregnancy. It can reduce total stage of labor and the incidence of cesarean section.

关 键 词：米索前列醇 药物引产 足月妊娠 药理机制 

分 类 号：R719.31[医药卫生—妇产科学] R984[医药卫生—临床医学]