心衰患者用卡维地洛心排量和血心钠素与一氧化氮的变化  

Effects of carvedilol on atrial natriuretic peptid, nitrogen oxide and cardiac output in the patients with congestive heart failure

作　　者：李月华[1] 董利军[1] 刘晓红[1] 赵美华[1] 

机构地区：[1]上海第二医科大学附属新华医院,上海200092

出　　处：《医师进修杂志》2004年第10期14-15,共2页Journal of Postgraduates of Medicine

摘　　要：目的　探讨充血性心力衰竭 (CHF)时用卡维地洛对血浆心钠素 (ANP)、一氧化氮 (NO)和心排量 (CO)变化的影响。方法　选择CHF患者 6 0例 ,随机分为对照组 (30例 )和治疗组 (30例 ) ,对照组采用综合治疗 ,治疗组在上述治疗的基础上加用卡维地洛 (1 0mg d) ,在治疗和观察期满 3、6个月分别测ANP、NO和CO。结果CHF患者用卡维地洛治疗后ANP、NO和CO各参数与对照组相比均有显著差异 (P <0 .0 5 )。结论　在CHF时血ANF、NO和CO的变化是心力衰竭病理生理的特征性变化 ,而卡维地洛则可以改善上述病理生理过程。Objective The changes of atrial natriuretic peptid (ANP), nitrogen oxide(NO) and cardiac output(CO) was studied in the patients with congestive heart failure(CHF) treated with carvedilol.Methods\ Sixty CHF patients were divided into the treatment group(30 cases) and the control group(30 cases) randomly . The general therapy was given to the control group. Besides this therapy, carvedilol(10 mg/d) was added to the treatment group. The ANP, NO and CO were studied in the CHF patients prior to and at the end of 3,6 months treatment respectively. Results\ The results showed that the levels of ANP, NO and CO were significant differences in these patients(P<0.05). Conclusion\ So carvedilol can help to improve the levels of ANP, NO and CO which are important pathophysiologic signs in the patients with CHF.

关 键 词：充血性心力衰竭 卡维地洛 心钠素 一氧化氮 心排量 

分 类 号：R541.6[医药卫生—心血管疾病]