氘和氚标记ST—1435的制备  

Preparation of deuterium and tritium labelled ST-1435

作　　者：张年宝[1] 彭庆义 钟德松[1] 章辛 徐平[2] 

机构地区：[1]中国科学院上海原子核研究所,上海201800 [2]中国科学院上海药物研究所,上海200031

出　　处：《核技术》1993年第9期537-539,共3页Nuclear Techniques

摘　　要：在氘或氚化溶剂中,16-次甲基-17α-乙酰氧基-19-羧基-孕甾-4-烯-3、20-二酮(Ⅰ)通过脱羧反应制得[10-~2H]ST-1435或[10-~3H]ST-1435(Ⅱ)。氘标记ST-1435经质谱分析表明有1—3个氘原子掺入到ST-1435分子中去,其中m/e 371(M^+)的氘掺入率为22.6％。氚标记ST-1435的比活度为52.5TBq/mol,放化纯度>95％。This paper reports the preparation of deuterium and tritium labelled ST-1435 (19-Nor-16-methylene-17 α-acetoxy-progesterone (Ⅱ)) by decarboxylation of 16-methylene-17α-acetoxy-19-oci acid-pregnen- 4-ene-3, 20-dione (Ⅰ) in deuterated or tritiated solvents. Deuterium incorportion rate for m/e 371(M+) was 22.6% as determined by mass spectrometer. The tritiated ST-1435 was obtained with a specific radioactivity of 52.5 TBq/mol and a radiochemical purity of over 95%.

关 键 词：氘 氚 标记化合物 脱羧基化 

分 类 号：R817.9[医药卫生—影像医学与核医学]