苦皮藤素的结构修饰及生物活性  

Synthesis and bioactivities of celangulin Ⅴ derivatives

作　　者：张继文[1] 姬志勤[1] 吴文君[1] 

机构地区：[1]西北农林科技大学农药研究所

出　　处：《西北农林科技大学学报（自然科学版）》2004年第10期99-101,共3页Journal of Northwest A&F University(Natural Science Edition)

基　　金：国家自然科学基金重点项目(30130130)

摘　　要：　根据天然杀虫活性物质苦皮藤素 分子结构含有C6-OH的特点,采用常规方法合成了苦皮藤素 的酯、酮及醚衍生物,其结构经1H-NMR确认。采用叶碟饲虫法,测定了合成衍生物对粘虫(Mythimnasepirata)的杀虫活性。结果表明,苦皮藤素 、酯、醚衍生物的LD50值依次为197.86,156.43和17.86μg/g,酮衍生物没有杀虫活性。Based on the character of celangulin Ⅴ molecule structure,acetylated,carbonylated and allyl ether derivatives of celangulin Ⅴ were designed and synthesized.Their structures were comfirmed (by^1H-NMR).The results of bioassay showed that the LD_(50) value of celangulin Ⅴ,acetylated and allyl ether derivative against the 3rd instar Mythimna sepirata lavae was 197.86,156.43 and 17.86 μg/g,respectively,and that carbonylated derivative had no insecticidal activity.

关 键 词：苦皮藤素V 结构修饰 生物活性 衍生合成 杀虫活性 生物源农药 

分 类 号：S481.9[农业科学—农药学]