秋水仙碱的电化学性质及电分析方法研究  

Study on the Electrochemical Characteristics and Electroanalytical Method of Colchicine

作　　者：冶保献[1] 木合塔尔.吐尔洪 张宗培[1] 曲松[1] 

机构地区：[1]郑州大学化学系,郑州450052 [2]新疆喀什师范学院化学系,新疆喀什844007

出　　处：《分析科学学报》2004年第5期458-460,共3页Journal of Analytical Science

基　　金：河南省自然科学基金(No.0211020400)

摘　　要：本文研究了抗癌药物秋水仙碱在玻碳电极上的电化学行为。在HAc NaAc缓冲溶液中,秋水仙碱在玻碳电极上产生一不可逆的氧化峰,峰电位为1.22V(vs.SCE)。用差示脉冲伏安法测定,峰电流与秋水仙碱浓度在8.00×10-7～1.00×10-5mol/L范围内有良好的线性关系,检出限达1.00×10-7mol/L。将之应用于模拟血清样品的测定,结果令人满意。同时,对电极反应机理进行了初步探讨。The electrochemical behavior of colchicine(COLC) is studied at the glassy carbon electrode. In 0.2 mol/L HAc-NaAc buffer (pH 4.60), an oxidative peak of COLC is obtained by cyclic voltammetry. The peak potential is at 1.22 V(vs.SCE). The anodic peak current obtained by differential pulse voltammetry is proportional to the concentration of COLC in the range of 8.0×10^(-7)～1.0×10^(-5) mol/L with the detection limit of 1.0×10^(-7)mol/L.The proposed method has been applied to the determination of COLC in human serum with satisfactory result. Moreover, the electrode reaction mechanism of the system is studied and some kinetics parameters are obtained too.

关 键 词：秋水仙碱 玻碳电极 差示脉冲伏安法 

分 类 号：O657.1[理学—分析化学] O629.3[理学—化学]