二元羧酸对草酸钙结晶的调控作用  

Effect of dicarboxylic acids on phases compositions of calcium oxalate

作　　者：周娜[1] 欧阳健明[1] 

机构地区：[1]暨南大学生物矿化与结石病防治研究所,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2004年第5期600-603,620,共5页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金重点项目(20031010);广东省自然科学重点基金(013202);广东省重点攻关项目(2001C31401);广东省"千百十工程"优秀人才培养基金(Q02060)资助项目

摘　　要：　采用双扩散法系统研究了凝胶体系中二元羧酸对尿结石主要成分草酸钙结晶的影响,这些羧酸分别为含有0、1、2个羟基的丁二酸、羟基丁二酸、酒石酸,含有1个氨基的L-天冬氨酸,以及含有双键的顺丁烯二酸、反丁烯二酸.对于丁二酸、羟基丁二酸和酒石酸的研究表明,随着羧酸中羟基数目的增加,抑制一水草酸钙(COM)聚集和诱导二水草酸钙(COD)生成的能力逐渐增强;随着羧酸浓度的增大,抑制COM聚集和诱导COD生成的能力也增强;随着结晶时间的增加,COM晶体钝化程度加深.对L-天冬氨酸、顺丁烯二酸和反丁烯二酸的研究表明,三者影响不明显.The effects of structurally-specific dicarboxylic acids on the phase compositions of calcium oxalate (CaOxa) crystals were investigated in gel by a double diffusion technique. All these acids were derived from butane diacid. They are succinic acid, DL-malic acid and tartaric acid which substituted by 0, 1 and 2 hydroxy groups, aspartic acid which derived from butane diacid 1 amino group, meleic acid and fumaric acid which have double-bonds. To the dicarboxylic acids substituted by hydroxy groups, their ability of inhibiting aggregation of calcium oxalate monohydrate (COM) and of inducing calcium oxalate dihydrate (COD) increased as increasing the number of the substituted hydroxy groups and as increasing the concentration of the acids. As the increase of crytallization time, COM became more and more blunter. For aspartic acid, meleic acid and fumaric acid, no significant effects on CaOxa growth was found.

关 键 词：草酸钙 尿结石 二元羧酸 凝胶 

分 类 号：O614.23[理学—无机化学] O623.621[理学—化学]