聚苯乙烯基N-甲基-N-酰基磺酰胺树脂的制备及其作为酰基转移试剂在酰胺合成中的应用  

PREPARATION AND APPLICATION OF A NEW ACYL TRANSFER REAGENT: POLYSTYRYL N-METHYL-N-ACYL-SULFONAMIDE RESINS

作　　者：李树锋[1] 罗君涛[1] 杨新林[1] 黄文强[1] 

机构地区：[1]吸附分离功能高分子材料国家重点实验室,南开大学高分子化学研究所,天津300071

出　　处：《离子交换与吸附》2004年第5期400-406,共7页Ion Exchange and Adsorption

基　　金：国家自然科学基金 (20074017)

摘　　要：聚苯乙烯基磺酰氯树脂 (树脂1) 与甲胺水溶液在吡啶的催化作用下反应,制备了N-甲基磺酰胺树脂 (树脂2).用酰氯在吡啶中与树脂2反应,得到N-酰基-N-甲基磺酰胺树脂 (树脂3).树脂3作为胺底物的酰基转移试剂,用来制备N-取代的酰胺,收率14~81%.树脂3可以有选择性地酰化乙醇胺中的氨基而不会使羟基酰化.Polystyryl sulfonyl chloride resin 1 reacted with aqueous methylamine in the presence of pyridine as catalyst yielding N-methyl sulfonamide resin 2, followed by treatment of acid chloride in pyridine to give polystyryl N-Methyl-N-acyl sulfonamide resin 3. N-Substituted amides were prepared by the reaction of amines with resin 3 as a acyl transfer reagent in 8-81% yields. Aminoethyl alcohol can be selectively acylated to offer N-hydroxylethyl benzamide without any esterification product.

关 键 词：聚苯乙烯基N—甲基—N—酰基磺酰胺树脂 酰基转移试剂 N—取代的酰胺 

分 类 号：O631.1[理学—高分子化学]