P物质在神经肌蒂移植治疗声带麻痹中的实验研究  

Substance P on reinervating vocal cord paralysis by neuromuscular pedicle transplantation

作　　者：刘涛[1] 王斌全[1] 皇甫辉[1] 夏立军[1] 张念祖[1] 

机构地区：[1]山西医科大学第一临床医学院耳鼻咽喉科,太原030001

出　　处：《山西医科大学学报》2004年第5期443-444,共2页Journal of Shanxi Medical University

基　　金：山西省卫生厅科研基金资助项目 ( 980 2 )

摘　　要：目的　探讨P物质对移植肌蒂生长所产生的作用。方法　将 2 0只健康杂种犬随机分为实验组和对照组 (n =10 )造成单侧联合性喉麻痹 ,取颈袢胸骨舌骨肌蒂移植治疗 ,实验组在肌蒂植入部位注入P物质 ,术后进行录音 ,直达喉镜、喉肌电图及相关酶学检查。结果　实验组和对照组电位幅度、波形有显著性差异 (P <0 .0 5 ) ,酶组化及图像分析无显著性差异 (P >0 .0 5 )。结论　P物质有望成为神经肌蒂移植治疗喉麻痹的辅助用药。Objective To study the effect of substance P (SP) on growth of neuromuscular pedicle (NMP) embedded. Methods Twenty dogs were divided into two groups randomly. In elected dogs, combined vocal cord paralysis models were made. These dogs were embedded by sternohyoid muscle pedicle of ansa cervicalis. In the two groups, one group were injected by SP. All cases had been subjected to postoperative voicerecording, laryngeal electromyography, and enmyze histochemical analysis. Results There was significant difference between the two groups on spontaneous abduction (P<0.05). Little difference was noted in enmyze histochemical analysis (P>0.05). Conclusion SP might be an auxiliary medicine for treating vocal cord paralysis by NMP transplantation .

关 键 词：声带麻痹 神经肌蒂移植 P物质 狗 

分 类 号：R767.91[医药卫生—耳鼻咽喉科]