调理心肾中药对拟痴呆大鼠脑组织中M和GABA受体功能的影响  

The effect of Heart- and Kidney- Benefiting Chinese Herbal Medicines on the function of cholinergic M- and Gamma ammo- butyric acid (GABA) receptor in brain tissues of analogue dementia rats

作　　者：莫启忠[1] 宫斌[1] 陈坤华[1] 方军[1] 李伟雄 王菊美[1] 匡兴伟[1] 陈荣[1] 

机构地区：[1]上海中医学院,上海200032 [2]深圳市中医医院

出　　处：《核技术》1993年第5期295-298,共4页Nuclear Techniques

摘　　要：以~3H-QNB和~3H-GABA为放射性配基,用受体放射性配基结合分析法,测出拟痴呆模型大鼠大脑皮层和海马组织中的M受体和小脑组织中的GABA受体的R_t值明显降低;M受体的K_D值在大脑皮层中明显减少,在海马中略有升高。小脑中GABA受体的K_D值显著降低。调理心肾中药及喜德镇(Hydergin,为国外常用抗老年痴呆药)能使降低的M受体和GABA受体的R_t值均明显升高,接近正常水平。对K_D值则有不同程度的调整作用。3H- QNB and 3H- GABA were used as radioactive ligand for M- and GABA receptors respectively. M- and GABA receptors were assayed by radioligand binding assay (RBA) in cerebral cortex, hippocampus and cerebellum of analogue dementia rats. It was found that Rt of M receptor was decreased in cerebral cortex and hippocampus and Rt of GABA receptor was decreased in cerebellum of analogue dementia rats. The dissociation constant (KD) of M- receptor was decreased significantly in cerebral cortex and KD value of GABA receptor was decreased in cerebellum of analogue dementia rats. The decreased Rt of M- and GABA receptor in brain tissue of analogue dementia rats was raised by Heart- and Kidney-Benefiting Chinese Herbs as well as hydergin.

关 键 词：胆碱能 衰茏 Γ氨基丁酸 心肾不交 

分 类 号：R817.1[医药卫生—影像医学与核医学]