白塞病患者抗淋巴细胞抗体的研究  

Changes of anti-lymphocyte antibody in patients with systemic Behcet's disease.

作　　者：舒展[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院

出　　处：《华中医学杂志》2004年第4期251-252,共2页Central China Medical Journal

摘　　要：目的　探讨白塞病 (BD)患者免疫功能失调的机制。方法　用微量淋巴细胞毒法检测 2 5例BD患者抗淋巴细胞抗体 (ALA) ,用光镜观察淋巴细胞形态及计数。结果　 2 5例BD活动期患者有 2 0例 (80 % )ALA阳性 ,淋巴细胞肿胀变性 ,胞膜毛糙 ,失去折光性 ,淋巴细胞计数为 (1.5 3± 0 .6 2 )× 10 9/L ,而经秋水仙碱和丹参治疗病情缓解后ALA阳性且淋巴细胞肿胀变性者仅 9例 (36 % ) ,淋巴细胞计数上升为 (3.5 3± 1.0 1)× 10 9/L。前后比较 ,经统计学处理 ,两者差异有极显著意义 (P <0 .0 1)。结论　BD患者活动期有 80 %体内存在ALA并导致淋巴细胞变性 ,细胞数目减少 ,提示BD患者存在免疫功能失调。Objective In order to investigate the mechanism of immunologic maladjustment in patients with Behcet's disease (BD).Methods Anti-lympthocyte antibody(ALA),lymphocytic shape and count were studied respectively in active and remissive BD with microlymphocytotoxicity.Results Positive ALA, degenerative lymphocyte swelling and losing dioptre were found in 80%(20/25)of patients with active BD, the lymphocyte count was ( 1.53± 0.62)×10 9/L. After administration of Immunosppressive agents., ALA positivity was dectected in 36%(9/25) of remissive BD;lymphocyte count went up to ( 3.53± 1.01)×10 9/L.There was significantly difference between two groups(P< 0.01).Conclusion Postive rate of ALA in active BD was higher than that in remissive patients, which could resulted in lymphocyte degeneration, decreased count and immunological disturbance. These could be reversed with Immunosppressive agents.

关 键 词：白塞病 抗淋巴细胞抗体 免疫功能失调 检测 

分 类 号：R597[医药卫生—内科学]