2型糖尿病患者脂蛋白(a)水平与冠状动脉病变的关系  

The Relationship between Levels of Serum Lipoprotein(a)and Coronary Artery Lesion

作　　者：范耀东[1] 刘玉洁[1] 

机构地区：[1]天津市胸科医院心内科

出　　处：《天津医药》2004年第8期471-473,共3页Tianjin Medical Journal

摘　　要：目的 :研究2型糖尿病患者血清脂蛋白(a)[LP(a)]水平与冠状动脉病变的关系。方法 :将368例按冠状动脉造影结果分为糖尿病合并冠心病 (A)组 ,单纯冠心病 (B)组 ,单纯糖尿病 (C)组和对照组 (D)4组 ,测定血脂水平。结果 :冠状动脉病变组 (A组和B组 )LP(a)水平高于无冠状动脉病变组 (C组和D组 ) ,差别有统计学意义(P<0.01) ,且A组LP(a)水平明显高于B组(P<0.01);LP(a)水平随着冠状动脉病变支数和积分的增加而递增 ;A组和B组LP(a)水平与冠状动脉病变积分之间呈明显的正相关 ,而LP(a)水平与A组正相关关系更为明显 (A组:r=0.62,t=5.42;B组 :r=0.45,t=3.25)。结论 :高水平LP(a)与糖尿病合并严重而弥漫的冠状动脉病变密切相关。Objective:To investigate the relationship between the levels of serum lipoprotein(a)[Lp(a)] and coronary artery lesion.Methods:Three hundred and sixty-eight patients who underwent selective coroˉnary artery angiography were divided into four groups which included coronary artery disease with diabetes mellitus(group A),coronary artery disease(group B),diabetes mellitus(group C),and the control group(group D).Levels of plasma apoprotein,LP(a)and other lipid components were measured respectively.Reˉsults:The levels of LP(a)in group A and B were significantly higher than that in group C and D,and there was a statistical difference between them(P<0.01).Within the lesion groups,the level of LP(a)in group A was significantly higher than that in group B(P<0.01).LP(a)level had a positive correlation with the severity of coronary artery lesions in group A and B.The positive correlation was more significant in group A(group A:r=0.62,t=5.42;group B:r=0.45,t=3.25).Conclusion:There might be a close relationship between high LP(a)and severity of coronary artery lesions with diabetes mellitus.

关 键 词：2型糖尿病 脂蛋白(a) 冠状动脉病变 冠状动脉造影 

分 类 号：R587.1[医药卫生—内分泌]