两种方法分析氟尿嘧啶在高氧液中的稳定性  

The stability of 5-fluorouracil in the hyperoxia solution determined by two analytical methods

作　　者：周瑾[1] 刘梅[1] 程建峰[1] 贺建荣[1] 

机构地区：[1]第四军医大学唐都医院药学部,陕西西安710038

出　　处：《华西药学杂志》2004年第4期286-287,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的　通过两种方法分析研究化疗药物氟尿嘧啶在高氧液中的稳定性。方法　将氟尿嘧啶分别溶于 2 5℃或 37℃的0 .9%氯化钠注射液或 0 .9%氯化钠注射液高氧液中 ,用紫外分光光度法和RP -HPLC法测定其含量的变化。结果　氟尿嘧啶在 0 .9%氯化钠注射液的高氧液中的含量与在 0 .9%氯化钠注射液中无明显区别 ,两种方法分析的结果之间差异不大。结论　氟尿嘧啶在高氧液中具有良好的稳定性 ,使用安全 ,为高氧液的化疗增敏作用的研究奠定了基础。OBJECTIVE To study the stability of 5-fluorouracil(5-Fu)in the hyperoxia solution by two different analytical methods.METHODS 5-Fu was dissolved in the 0.9% NaCl injection or in the hyperoxia 0.9%NaCl solution.At 25℃ or 37℃,the contents of 5-Fu were determined by HPLC and UV,respectively.RESULTS 5-Fu contents in 0.9% NaCl injection and the hyperoxia solution did not have distinct differences,which were assayed by HPLC and UV method.CONCLUSION 5-Fu is stable in the hyperoxia solution,which provide the foundation to the study of chemosensitivity.

关 键 词：氟尿嘧啶 高氧液 稳定性 高效液相色谱法 紫外分光光度法 

分 类 号：R917[医药卫生—药物分析学]