二氧化碳-氦-氖激光治疗斑秃的临床和实验研究  

The clinical and experimental study of CO_2-He-Ne laser therapy on alopecia areata

作　　者：卢浩锵[1] 黄卓辉[1] 简锦彪 冯惠明[1] 朱健[3] 罗肖萍[4] 

机构地区：[1]广州医学院第一附属医院皮肤科,广州510120 [2]广州市激光技术应用研究所 [3]广州医学院第一附属医院激光科,广州510120 [4]广州医学院第一附属医院病理科,广州510120

出　　处：《中华物理医学与康复杂志》2004年第8期484-486,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：广东省医学科学技术研究基金 (No.A70 0 0 2 68)

摘　　要：目的　观察激光全头皮照射治疗斑秃的临床疗效和激光对实验性脱毛动物的毛发生长作用。方法　选择 72例斑秃患者 ,随机分为治疗组 (3 8例 )和对照组 (3 4例 ) ,所有患者均口服胱氨酸片和左旋咪唑片 ;治疗组在此基础上采用二氧化碳 氦 氖 (CO2 He Ne)激光治疗仪作扩束垂直全头皮照射 ,观察 2组患者治疗后毛发的生长情况。用小功率CO2 激光仪照射人工脱毛豚鼠 ,观察其对动物毛发生长的刺激作用。结果　临床研究发现 ,治疗组临床治愈率为 71.0 % ,总有效率为 94.7% ,与对照组比较 ,差异有非常显著性意义(P <0 .0 1)。动物实验结果 :激光照射侧豚鼠毛每日增长 (0 .710± 0 .0 3 5 )mm ,与对照侧比较 ,差异有非常显著性意义 (P <0 .0 1) ;病理观察发现 ,豚鼠激光照射侧皮肤标本与对照侧比较 ,毛囊数目明显增加 ,部分区域有血管充血现象。结论　CO2 He Ne激光能明显促进毛发的生长 ,对治疗斑秃有显著的临床疗效。Objective To observe the therapeutic effect of CO 2 He Ne laser irradiation on alopecia areate, and to observe the effect of CO 2 laser on hair growth in rats with experimental alopecia areate. Methods Seventy four alopecia areate patients were recruited, 38 allocated in the observation group, 34 in the control group. The observation group was dealt with CO 2 Ne Ne laser irradiation therapy and oral administration cystine and levamisole, and the control group was dealt with oral medication simply. Clinic changes were observed.The experimental study was measuring and comparing the hair growth between artificial depilated rats with and without CO 2 laser therapy. Results CO 2 He Ne laser therapy could cure alopecia areate in 71.0% of the patients, and the total effectiveness rate was 94.7%.A significant difference between the control and the observation groups was revealed ( P <0.01).The average length of hair growth in laser therapy zone was 0.710±0.035mm per day in the rats, which was significantly different with that of the control group ( P <0.01). Pathologicalexamination showed significant increase of the number of hair follicle in the observed zone as compared with that of the control group. Conclusion CO 2 He Ne laser therapy has significant effect in treating alopecia areate, it can increase the hair growth level.

关 键 词：二氧化碳-氦-氖激光 斑秃 CO2-He-Ne 激光治疗 皮肤科 皮肤病 心理压力 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]