前列冲剂对大鼠前列腺增生影响的实验研究  

An Experimental Study on the Inhibition of Prostatic Hyperplasia in Rats with Qianlie Granute

作　　者：廖泽云[1] 邓丽群[1] 黄德彬[1] 

机构地区：[1]湖北民族学院医学院,湖北恩施445000

出　　处：《湖北民族学院学报（医学版）》2004年第3期16-18,共3页Journal of Hubei Minzu University(Medical Edition)

基　　金：湖北省恩施州科技局科研资助项目 (2 0 0 2A0 1 1 )

摘　　要：目的　观察前列冲剂对去势大鼠前列腺增生的影响。方法　将 32只雄性昆明大鼠随机分为 4个组 ,除对照组外 ,实验组大鼠均做去势手术 ,7d后实验组 1皮下注射生理盐水 ,每天二次 ;实验组 2皮下注射丙酸睾丸酮 (4ml/kg) ,同时用生理盐水灌胃 ,每天两次 ;实验组 3皮下注射丙酸睾丸酮 (4ml/kg) ,同时用前列冲剂灌胃 (5ml/kg) ,每天两次。 5周后将大鼠处死 ,取出前列腺用 1 0 %福尔马林固定 ,常规HE染色 ,光镜观察。结果　与正常对照组比较 ,实验组 3大鼠前列腺组织有明显萎缩 ,而且主要表现为间质萎缩。Objective The effects of qianlie granute was observed to inhibit rat prostate growth.Methods An experimental model of prostatic hyperplasia of castrated male rat induced by testosterone propionate was made.The rats were randomly apportioned into normal control group, testosterone propionaste (TP)group,qianlie granute and TP group,TP was subcutaneously injected into rat two times every day.Finally HE dying prostatic tissues section were observed.Results Qianlie granute could significantly inhibit rat prostatic hyperplasia induced by testosterone propionate. HE dying prostatic tissues section shows that rat prostatic hyperplasia was inhibited.Conclusion Qianlie granute could significantly inhibit rat prostatic hyperplasia induced by testosterone propionate.

关 键 词：前列冲剂 前列腺增生 动物实验 

分 类 号：R285.5[医药卫生—中药学]