超灵敏TSHCLIA动态监测在预测甲亢复发中的临床意义  

Clinical Value of Predicting Recurrent Patients with Hyperthyroidism by Serum Concentration Variations of Supersensitive TSH-CLIA

作　　者：孙丽明[1] 赵维[1] 黄玉华[2] 

机构地区：[1]沈阳医学院附属中心医院内分泌科,辽宁沈阳110024 [2]沈阳医学院附属中心医院放免室,辽宁沈阳110024

出　　处：《沈阳医学院学报》2004年第3期133-133,145,共2页Journal of Shenyang Medical College

摘　　要：目的 :采用超灵敏TSH 化学发光免疫分析方法 (TSH CLIA) ,动态监测甲亢患者血清TSH浓度 ,探讨其在预测甲亢复发中的意义。方法 :分为短疗程停药观察组 (A组 )和甲亢缓解组 (B组 ) ,A组 12例 ,抗甲亢药物治疗少于 1年。B组 8例 ,常规抗甲亢药物治疗 1.5年。结果 :A组 6例动态观察半年后FT3 .FT4同时升高。B组TSH <0 .1mIU/L 2例 ,随访 1年 ,有 1例FT3 升高。结论 :TSH <0 .1mIU/L的甲亢患者应定期监测TSH .FT3 .FT4。TSH CLIA可预测甲亢复发病例且优于FT3 .FT4。Objective: To study the clinical value of predicting recurrent patients with hyperthyroidism by serum concentration variations of supersensitive thyrotrophin-Chemiluminescent immunoassay (TSH-CLIA). Methods: A group had 12 cases with short durance (antithyrotoxic therapy <1 year). B group had 8 cases with hyperthyroidism releaved by routine therapy (antithyrotoxic therapy 1.5 year). Results: FT 3. FT 4 were increased at the same time in 6 cases of A group with TSH<0.003mIU/L after half year. FT 3 was increased in one case of two patients with TSH< 0.1mIU/L of B group after observing one year. Conclusion: FT 3. FT 4 . TSH should be monitored in periodic time in the patients with hyperthyroidism and is superior to FT 3 .FT 4 in predictinhg recurrent patient.

关 键 词：甲亢 复发 FT3 治疗 FT4 灵敏 TSH-CLIA 超灵敏TSH-化学发光免疫分析方法 

分 类 号：R581.1[医药卫生—内分泌] R446[医药卫生—内科学]