硝酸异山梨酯静脉滴注对冠心病病人血管内皮功能的影响  

Influence of isosorbide dinitrate intravenous dropping on vascular endothelial function of coronary artery disease patients

作　　者：黄震华[1] 许左隽[1] 朱雅琴[1] 朱文敏[1] 

机构地区：[1]上海第二医科大学附属第九人民医院心血管病研究室,上海200011

出　　处：《中国新药与临床杂志》2004年第10期655-658,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :观察硝酸异山梨酯静脉滴注对冠心病病人血管内皮功能的影响。方法 :6 4例冠心病病人随机分为 2组 ,硝酸异山梨酯组 (32例 )予硝酸异山梨酯 2 0mg ,iv ,gtt,qd ;复方丹参组 (32例 )予复方丹参 2 0mL ,iv ,gtt ,qd。均连续用药 4wk。结果 :硝酸异山梨酯组治疗后 6 酮前列腺素F1α(99± 6 9)ng·L- 1]、一氧化氮 [(134± 88) μmol·L- 1]均较治疗前 [(75± 5 8)ng·L- 1,(91± 85 ) μmol·L- 1]上升 ,血组织型纤溶酶原激活物抑制物 [(0 .6 4± 0 .2 7)×10 3AU·L- 1vs (0 .5 4± 0 .2 4 )× 10 3AU·L- 1]、凝血烷B2 [(111± 2 31)ng·L- 1vs (71± 14 6 )ng·L- 1]、内皮素 1[(98± 6 2 )ng·L- 1vs (80± 4 7)ng·L- 1],浓度均下降 (P <0 .0 5 ,P <0 .0 1)。复方丹参组无此变化 (P >0 .0 5 )。结论AIM: To observe the influence of isosorbide dinitrate intravenous dropping on the vascular endothelial function of coronary artery disease patients. METHODS: Sixty-four coronary artery disease patients were divided randomly into the isosorbide dinitrate group(32 patients) and Salvia miltiorrhiza compound group(32 patients). In isosorbide dinitrate group, isosorbide dinitrate 20 mg was dripped iv, gtt, qd for 4 wk, and in Salvia miltiorrhiza compound group, Salvia miltiorrhiza compound 20 mL was dripped iv, gtt, qd for 4 wk. RESULTS: After treatment, the blood 6-keto PGF 1α((75±58) ng·L -1 vs (99±69) ng·L -1) and NO((91±85) μmol·L -1 vs (134±88) μmol·L -1) concentration increased, and PAI((0.64±0.27)×10 3AU·L -1 vs (0.54±0.24)×10 3AU·L -1), TXB 2((111±231) ng·L -1 vs (71±146) ng·L -1) and ET-1((98±62) ng·L -1 vs (80±47) ng·L -1) concentration decreased in isosorbide dinitrate group compared with those before treatment. In Salvia miltiorrhiza compound group, above changes did not occur. CONCLUSION: Isosorbide dinitrate intravenous dropping may improve the vascular endothelial function of coronary artery disease patients.

关 键 词：异山梨酯 硝酸 冠状动脉疾病 内皮 血管 一氧化氮 内皮缩血管肽1 血管内皮功能 

分 类 号：R972[医药卫生—药品] R541.4[医药卫生—药学]