曲唑酮治疗失眠症  

Trazodone in treatment of insomnia

作　　者：耿晓芳[1] 顾之光[1] 季闽春[1] 

机构地区：[1]华东医院临床药理室,上海200040

出　　处：《中国新药与临床杂志》2004年第10期699-701,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :观察曲唑酮治疗失眠症的疗效。方法 :38例符合 (CCMD 2 R)诊断标准的失眠症病人分为 2组 ,曲唑酮组 2 2例 ,在原有催眠药物减量条件下加服曲唑酮 2 5～ 5 0mg·d- 1,qn ,对照组 16人 ,维持原有催眠药物治疗。结果 :匹兹堡睡眠质量指数 (PSQI)评分 :曲唑酮组PSQI总分 (12±s 4 )分 ,对照组PSQI总分 (12± 4 )分 (P >0 .0 5 )。曲唑酮组催眠药逐渐减量 ,有 8例停用催眠药。结论 :曲唑酮与催眠药催眠作用相仿 ,曲唑酮可帮助长期服用催眠药的失眠病人逐渐减少催眠药用量 。AIM: To observe the efficacy of trazodone in the treatment of insomnia. METHODS: Thrity-eight patients met the CCMD-2-R criteria of insomnia were divided into two groups. Twnety-two patients in trazodone group were treated with trazodone 25-50 mg·d -1,qn,while tapered the dose of previous hypnotics. Sixteen patients in control group continued to treat with previous hypnotics. RESULTS: Pittsburgh Sleep Quality Index grading:trazodone group was (12±s 4), control group was (12±4). There was no significant difference between two groups (P>0.05). Eight patients in trazodone group stopped taking hypnotics. CONCLUSION: The efficacy of trazodon group is similar to that of hypnotics. Trazodone can gradually reduce the dose of hypnotics and relieve BZ-dependent patients' pain.

关 键 词：曲唑酮 苯二氮革类 入睡和睡眠障碍 药物疗法 

分 类 号：R971.43[医药卫生—药品] R749.7[医药卫生—药学]