2-甲硫基-1-苯基乙酮苯甲酰腙类化合物的合成和生物活性  

Synthesis and Bioactivity of 2-Methylthio-1-phenylethanone Benzoylhydrazones

作　　者：黄明智[1] 黄可龙[1] 陈灿[2] 黄路[2] 张承来[2] 王永江[2] 

机构地区：[1]中南大学化学化工学院,湖南长沙410083 [2]湖南省化工研究院,湖南长沙410007

出　　处：《农药学学报》2004年第3期67-70,共4页Chinese Journal of Pesticide Science

基　　金：国家自然科学基金资助项目(20372021);湖南省自然科学基金资助项目(03JJY3018).

摘　　要：为寻找新型结构的农药先导化合物,采用2-甲硫基-1-取代苯基乙酮与取代苯甲酰肼反应合成了11个2-甲硫基-1-苯基乙酮苯甲酰腙类化合物,其化学结构经质谱、1H核磁共振与元素分析确证。生物活性试验结果表明,部分化合物具有杀菌或杀虫活性,如2-甲硫基-1-(4-甲基苯基)乙酮-4-氯苯甲酰腙( j)在500mg/L时对黄瓜灰霉病菌B.cinerea、小麦赤霉病菌G.zeae具有良好的杀菌活性,其抑制率达到95%以上。In search of pesticide lead compound with new structure type, eleven novel (2-methylthio)-1-phenylethanone benzoylhydrazones were designed and synthesized by reacting (2-methylthio) substituted acetophenone with substituted benzoylhydrazones. Their structures were confirmed by MS, ()~1H NMR and elemental analysis. The preliminary bioassay showed that some of title compounds had fungicidal activities or insecticidal activities, for example, (2-methylthio)-1-(4-methylphenyl)ethanone 4-chloro-benzoylhydrazone exhibited more than 95% (inhibition) against Botrytis cinerea and Gibberella zeae at 500 mg/L.

关 键 词：腙 合成 生物活性 

分 类 号：O622.4[理学—有机化学]