睾丸支持细胞与生精细胞凋亡的关系  

Relationship between the Sertoli Cell and Germ Cell Apoptosis

作　　者：张继强[1] 秦达念[1] 

机构地区：[1]汕头大学医学院生理学教研室,广东汕头515031

出　　处：《中华男科学杂志》2004年第9期688-691,共4页National Journal of Andrology

基　　金：广东省自然科学基金 ( 0 2 2 2 72 0 );汕头大学研究与发展基金 (L0 0 0 0 3 )资助

摘　　要：生精细胞处于支持细胞构造的环境中 ,激素、生长因子和温度以及它们与支持细胞的联系调控着生精细胞的分化与成熟 ;细胞之间的旁分泌信号转导亦调节着生精细胞凋亡的过程。在睾丸生精细胞发生的自发性凋亡和诱发性凋亡中 ,支持细胞表达和分泌的产物扮演重要角色。Germ cells exist in an environment created by Sertoli cells. The differentiation of germ cells from spermatogonia to sperm in the seminiferous epithelium is controlled by many factors such as hormones, growth factors, temperature and interaction with Sertoli cells. Paracrine signaling between these intimately associated cells also regulates the process of germ cell death. Sertoli cells' products play an important role in the process of germ cell differentiation in the testis, in which both the spontaneous and induced germ cell apoptosis often occur.

关 键 词：支持细胞 生精细胞 凋亡 

分 类 号：R698.2[医药卫生—泌尿科学]