慢性肺心病急性期患者血液中一氧化氮与SOD、LPO含量变化及意义  

Clinical significance of determination of serum NO、SOD and LPO in old patients with Cor pulmonale of acute onset

作　　者：陈美云[1] 林其昌[1] 黄志华[1] 吴武松[1] 陈公平[1] 

机构地区：[1]福建医科大学附属第一医院呼吸内科,福州市350005

出　　处：《心血管康复医学杂志》1999年第3期8-10,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的 :为了探讨一氧化氮 (NO)和超氧化物岐化酶 (SOD)、过氧化脂质 (L PO)在慢性肺心病急性期患者血液中含量变化关系及其意义。方法 :应用比色法测定 32例老年慢性肺心病患者血液中 NO及 SOD、L PO水平。结果 :老年肺心病急性期血清 NO和 SOD含量明显降低 ,血浆 L PO含量明显增高 ,与正常对照组比较均有显著性差异 (P<0 .0 1)。结论 :慢性肺心病急性期患者血清 NO含量与氧自由基损伤程度有密切关系。一氧化氮减少可能是慢性肺心病急性期形成肺动脉高压的主要因素之一。而氧自由基可能参与慢性肺心病急性期的病理生理过程。Objective:To study the changes and significance of serum NO,SOD and plasma LPO in patients with Cor pulmonale of acute onset.Methods:The blood samples of 32 cases of Cor pulmonale were determined by colorimetry.Results:The results indicated that the contents of serum NO and SOD in cases with Cor pulmonale of acute onset remarkably decreased while plasma LPO increased,it is in significant differnce( P <0 01) from normal controls.Conclusion:These results suggest that the contents of serum NO in cases with Cor pulmonale of acute onset is closely related to the oxygen\|free radical injury.The NO may be one of the main factors in the development of pulmonary arterial hypertension.The oxygen\|free radical may be involved in the pathophysiological process of acute phase of Cor pulmonale.

关 键 词：急性期 慢性肺心病 LPO SOD 血液 一氧化氮 血清 老年肺心病 

分 类 号：R541.5[医药卫生—心血管疾病] R743[医药卫生—内科学]