慢性充血性心力衰竭患者血内皮素、心钠素、内洋地黄素浓度变化的临床意义  

Clinical significance of changes of plasma endothelin,atrial natriuretic peptide and serum endogenous digitalis like factor in 332 patients with chronic congestive heart failure

作　　者：曾祥鸿 林锡静 李芸芸 赵豫琴 聂晓莉 李茂琼 刘朝晖 程小云 

机构地区：[1]成都市第二医院,四川省成都市610017

出　　处：《心血管康复医学杂志》1999年第3期12-15,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的 :研究血内皮素 (ET)、心钠素 (ANF)、内洋地黄素 (EDF)与慢性心衰病因和程度的关系。方法 :对 332例慢性心衰患者测定了 ET、EDF、ANF,并作了平均 11月的随访。结果 :正常人年龄、性别对 ET、EDF、ANF无影响。心衰组 ET、ANF明显增加 (P<0 .0 0 1) ,与心衰呈正相关 ,EDF明显下降 (P<0 .0 0 1) ,与心衰呈负相关。结论 :同步监测 EF、ANF、EDF释放调节有助于早期发现心衰 ,判断病情及预后。Objective:To investigate the clinical significance of changes of plasma endothelin(ET),atrial natriurtic peptide(ANP) and endogenousdigitalis like factor(EDF) in chronic congestive heart failure(CHF).Methods:Determination of plasma ET,ANP and Serum EDF was carried out in 332 patients with CHF by radioimmunoassay and follow up (mean 11±7 months) was performed.Results:The concentration of plasma ET and ANP in CHF were significantly higher than that in normal and serum EDF in CHF was significant lower than that in normal (All P <0 001).The lowering of EDF was significantly negatively correlated to the severity of CHF,the raising of ET and ANP was significantly positively correlated to the severity of CHF.Conclusion:Dynamic observation of changes of ET,ANP and EDF may be very useful in judgement of severity and prognosis on patients with CHF.

关 键 词：ANF ET 慢性心衰 血内皮素 心钠素 内洋地黄素 慢性充血性心力衰竭 

分 类 号：R541[医药卫生—心血管疾病] R743[医药卫生—内科学]