胃祺饮阻断胃癌前病变细胞增殖的临床观察  

Clinical Observation of“Stomach Fortune Drink”In Blocking Proliferation of Morbid Cells Before Gastric Cancer

作　　者：马贵同[1] 龚雨萍[1] 胡鸿毅[1] 陆雄[1] 柳文[1] 谢建群[1] 

机构地区：[1]上海中医药大学附属龙华医院胃肠病研究室,上海200032

出　　处：《上海中医药大学学报》1999年第3期20-22,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市教委基金! 96C0 6

摘　　要：为观察胃祺饮逆转慢性萎缩性胃炎合并胃癌前病变细胞及其抗自由基损伤作用 ,收集慢性萎缩性胃炎伴不完全大肠化生或伴中度不典型增生患者 6 0例 ,随机分为中药胃祺饮治疗组 3 0例 ,西药叶酸对照组 3 0例 ,分别予胃祺饮及叶酸口服 ,共 3月。观察治疗前后胃粘膜肠化组织切片中硫酸粘液转化率、增殖细胞核抗原 (PCNA)、ras癌基因蛋白P2 1表达变化 ,以及胃液中过氧化脂质 (LPO)和谷胱甘肽过氧化物酶 (GSH -Px)活性变化。结果表明 :中药组硫酸粘液转阴率为 76 .6 7% ( 2 3 /3 0 ) ,治疗前后PCNA、P2 1蛋白表达和LPO活性明显下降 ,GSH -Px活性上升 ,较西药组有显著差异 ,从而证实胃祺饮不仅能阻断促癌过程中的氧化损伤 ,对胃癌前病变细胞的增殖也有良好的逆转作用。Inordertoobservethefunctionsof“Stomach FortuneDrink”inreversingchronicatrophicgastritis complicatedwithprecancerousmorbidcellsandinresist ingfreeradical ,60casesofthepatientswithchronicat rophicgastritisaccompaniedbyincompleteintestinal metaplasiaormediumnon typicalproliferationwerecol lectedanddividedrandomlyintothetreatmentgroupof 30 casestreatedbyChineseherbal“StomachFortuneDrink” andthecontrolgroupof 30casestreatedbyfolacin .They wererespectivelygiven“StomachFortuneDrink”andfo lacinorallyfor 3monthstoobservesulfate mucustransfor mationrate ,proliferativecellnucleusantigen (PCNA ) , changeinexpressionofrasoncogeneproteinP2 1inslices ofintestinalmetaplasiatissuesofgastricmucosaandthe activechangeoflipidperoxide(LPD)andglutathioneper oxidase(GSH Px)ingastricjuicebeforeandaftertreat ments .TheresultsshowedthatinChineseherbalgroup , thenegative transformationrateinsulfatemucuswas 76. 67% ( 2 3/ 30 ) ,PCNA ,P2 1proteinexpressionandLPD activitydecreasedremarkablyandGSH Pxactivityin creasedbeforeandaftertreatments ,significantlydifferent thaninthemedicationgroup .Consequently ,itisproved that“StomachFortuneDrink”notonlycanblocktheoxi dizinginjuryduringcarcinogenicprocessandalsohasbet terreversingfunctioninproliferationofmorbidcellsbe foregastriccancer .

关 键 词：胃祺饮 胃癌前病变 硫酸粘液转化率 增殖细胞核抗原 蛋白P21 抗自由基损伤 

分 类 号：R285.6[医药卫生—中药学]