更昔洛韦治疗婴儿巨细胞病毒肝炎疗效观察  

Observation of curative effect of ganciclovir on infant cytomegalovirus hepatitis

作　　者：熊菀[1] 朱朝敏[1] 

机构地区：[1]重庆医科大学儿童附属医院,重庆400014

出　　处：《儿科药学杂志》2004年第5期23-24,共2页Journal of Pediatric Pharmacy

摘　　要：目的探讨更昔洛韦治疗婴儿巨细胞病毒肝炎的临床疗效。方法对30例临床诊断为巨细胞病毒肝炎的婴儿采用更昔洛韦诱导治疗和维持治疗共28d,治疗前后分别检测其肝功能和肝脏大小,CMV鄄IgM,部分检测CMV鄄DNA。结果治疗后患儿肝功能中总胆红素、直接胆红素、丙氨酸转氨酶显著性降低,肝脏肿大明显缩小。治疗28d后CMV鄄IgM转阴率为69%,CMV鄄DNA转阴率为44%。结论更昔洛韦治疗婴儿巨细胞病毒肝炎在恢复肝功能、缩小肝脏肿大和抑制病毒复制有一定疗效,副作用较小,临床使用安全。Objective: To study the clinical effect of ganciclovir (GCV) in treatment of the 30 infants with cytomegalovirus (CMV) hepatitis. Methods: 30 infants with CMV hepatitis were treated with GCV for 28 days. The liver function, size, and CMV-IgM part of CMV-DNA were detected. Results: There were significant differences in liver function and its size before and after treatment. Negative rates of CMV-IgM and CMV-DNA were 69% and 44%. Conclusion: The use of GCV in infant CMV hepatitis was effective on recovering of liver function, which reduced the size of liver and check the CMV replication. No obvious side-effects were found in its clinical use.

关 键 词：婴儿 巨细胞病毒肝炎 更昔洛韦 

分 类 号：R978.7[医药卫生—药品]