溴代环丙烷的合成工艺改进  

Improved Preparation of Bromocyclopropane

作　　者：张文楠[1] 李天仚[1] 崔惠芳[1] 朱靖[1] 

机构地区：[1]河南省科学院精细化工重点实验室,河南郑州450002

出　　处：《中国医药工业杂志》2004年第10期582-583,共2页Chinese Journal of Pharmaceuticals

摘　　要：γ-丁内酯用氯化亚砜氯化后无需分离直接用甲醇酯化,所制得的V-氯丁酸甲酯在季铵盐类相转移催化剂作用下闭环、水解得到的环丙烷甲酸再经脱羧和溴化反应得溴代环丙烷,总收率59%。Bromocyclopropane was synthesized from g-butyrolactone by chlorination and esterification to givemethyl 4-chlorobutyrate, which subjected to cyclization and hydrolysis to afford cyclopropane carboxylic acid and thenfollowed by decarboxylation and bromination with an overall yield of 59%.

关 键 词：溴代环丙烷 中间体 合成 

分 类 号：O623.21[理学—有机化学]