利福布汀胶囊溶出度测定  

Dissolution of Rifabutin Capsules

作　　者：田治科[1] 潘一斌[2] 

机构地区：[1]浙江大学药学院,浙江杭州310031 [2]浙江医药股份有限公司新昌制药厂,浙江新昌312500

出　　处：《中国医药工业杂志》2004年第10期619-620,共2页Chinese Journal of Pharmaceuticals

摘　　要：建立了紫外分光光度法测定利福布汀胶囊的溶出度。采用中国药典2000版附录ⅩC第一法,以0.01mol/L盐酸为溶出介质,转速100r/min,测定波长280nm。利福布汀在2.5～25mg/ml浓度范围内线性关系良好(r=0.9999),平均回收率98.3%(RSD 0.60%)。并以进口样品为对照进行溶出试验,结果表明两者前15min的溶出特性存在差异。The dissolution of rifabutin capsules was determined by UV method, according to the first methodof appendix ⅩC in Ch.P. 2000 at the detection wavelength of 280nm, under the stirring speed of 100r/min and in thedissolution solution of 0.01mol/L HCl. The calibration curve of rifabutin was linear in the concentration range of 2.5～25mg/ml. The average recovery was 98.3% (RSD 0.60%). The dissolution test of domestic and imported products showedthat two products had different dissolution characteristic in the first 15min.

关 键 词：利福布汀 胶囊 溶出度 紫外分光光度法 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.32[化学工程—制药化工]