4-甲基-5-(β-羟乙基)-噻唑的制备  

Preparation of 4-Methyl-5-(β-Hydroxyethyl)-Thiazole

作　　者：王鹏[1] 辛菲[1] 李海华[1] 杜西莹[1] 

机构地区：[1]北京理工大学化工与环境学院,北京100081

出　　处：《北京理工大学学报》2004年第9期821-824,共4页Transactions of Beijing Institute of Technology

摘　　要：由α-乙酰-γ-丁内酯出发,经氯化,水解脱羧,合环,重氮化,还原5步反应,合成了4-甲基-5-(β-羟乙基)-噻唑.采用硫酸代替盐酸避免了副产物2-氯-4-甲基-5-(β-羟乙基)-噻唑的生成,采用一锅法完成了目标物的制备,显著提高了重氮化还原过程中的收率,简化了工艺,总收率可达70%.4-methyl-5-(β-hydroxyethyl)-thiazole was prepared, starting from α-acetobutyro-lactone, by chloronation, hydrolysis and decarboxylation, cyclization, diazotization and reduction. The yield of diazotization and reduction was remarkably increased and the procedure was simplified by the use of H_2SO_4 in place of HCl, thus avoiding the formation of the by-product (2-chloro-4-methyl-5-(β-hydroxyethyl)-thiazole,) and finished the preparation of the object product in a one pot process. The total yield reached 70%.

关 键 词：4-甲基-5-(β-羟乙基)-噻唑 重氮化 α-乙酰-γ-丁内酯 2-氨基-4-甲基-5-(β-羟乙基)-噻唑 一锅法合成 

分 类 号：O626.25[理学—有机化学]