新型光量子对血透患者慢性炎症反应状态的干预作用  

The Interfere Effect of New Photons on Chronic Inflammatory Reaction in Patients treated with Hemodialysis

作　　者：吕伯东 胡青 马寅峰 杨克冰 张士更 赵晓黎 张清芳 许凌宇 王寅 朱琮[3] 

机构地区：[1]浙江中医学院附属新华医院泌尿外科血透室,杭州310005 [2]浙江中医学院附属新华医院化验室,杭州310005 [3]浙江大学附属第一医院透析肾移植中心,杭州310005

出　　处：《中国中西医结合肾病杂志》2004年第10期581-582,共2页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：浙江省教育厅基金资助项目 (No .2 0 0 2 0 3 2 7)

摘　　要：目的 :探讨新光量子疗法在干预血透患者慢性炎症反应状态中的效果。方法 :随机选择 2 0例终末期肾病 (ESRD)维持性血透患者 ,应用自行设计光量子导管与血透管路连接 ,在透析过程中对其血液直接进行紫外线的照射治疗 ,检测治疗前、治疗后 1月、治疗后 2月C反应蛋白及白介素 - 6水平。结果 :治疗 1月后C反应蛋白水平为(4 .0 0± 1.73)mg/L明显低于治疗前 (6 .12± 2 .76 )mg/L ,有统计学差异 (P <0 .0 1) ;白介素 - 6水平治疗后 (0 .2 2±0 .0 3)ng/ml,与治疗前 (0 .2 2± 0 .0 6 )ng/ml比较 ,无统计学差异 (P >0 .0 5 )。治疗 2月后白介素 - 6水平 (0 .14±0 .0 2 )ng/ml也已明显低于治疗前 ,有统计学差异 (P <0 .0 5 )。结论 :新光量子疗法是安全、方便、有效的 ,联合血透治疗可改善血透患者慢性炎症反应状态 ,有利于降低终末期肾病患者透析并发症和提高其生活质量 。Objective:To study the effect of the new pattern photon therapy in interfering the inflammatory reaction in patients treated with hemodialysis.Methods:20 patients with end-stage renal disease (ESRD) were recruited at random,and the self-designed new pattern photons therapy was actualized during the process of dialysis,with which the blood was directly irradiated with the ultraviolet rays.The levels of C-response protein and IL-6 were examined before the treatment,and one month and two months after the treatment.Results:After one month's treatment, the level of C-response protein was (4.00±1.73)mg/L which was obviously lower than the value of (6.12±2.76)mg/L before the treatment(P<0.01) with significant statistic difference (P<0.01), while IL-6 was (0.22±0.03)ng/ml which had no statistical difference when compared with the value of (0.22±0.06)ng/ml before the treatment without statistical significance(P>0.05).After two months' treatment,the levels of IL-6 (0.14±0.02)ng/ml also became lowered than before the treatment with a statistical difference (P<0.05).Conclusion:The new pattern photon therapy was safe,easy to operate and effective,which can be used during hemodialysis to improve the chronic inflammatory reaction in patients treated with dialysis and to lower the dialytic complications in ESRD patients and to increase their living qualities. Therefore it is a method worth of being popularized.

关 键 词：治疗前 血透患者 慢性炎症 治疗后 光量子疗法 终末期肾病 白介素-6 干预作用 C反应蛋白 并发症 

分 类 号：R692.5[医药卫生—泌尿科学]