玻璃基骨水泥生物活性的研究  

Investigation on Bioactivity of Glass Based Bone Cement

作　　者：付强[1] 周萘[1] 黄文旵[1] 王德平[1] 

机构地区：[1]同济大学材料科学与工程学院,上海200092

出　　处：《同济大学学报（自然科学版）》2004年第9期1178-1182,共5页Journal of Tongji University:Natural Science

基　　金：国家自然科学基金资助项目 (5 0 2 72 0 41) ;上海市科委纳米技术专项发展基金资助项目 (0 14 4nm0 64 )

摘　　要：以CaO SiO2 P2 O5系统生物玻璃和磷酸铵调和液混合制得玻璃基生物骨水泥 (GBC) ,利用X 衍射 (XRD)、扫描电镜 (SEM )和红外光谱 (FTIR)对产物的晶相、化学组成和显微结构进行了分析 .结果表明 ,随着浸泡时间的增加 ,玻璃基骨水泥 (GBC)中的玻璃相逐步向类骨状羟基磷灰石 (HAP)微晶转化 ,所生成的HAP晶体端面尺寸分布在 30～ 5 0nm之间 ,这表明GBC中所生成的HAP晶体与人体骨中生物HAP很相似 ,会具有良好的生物活性 .FTIR的结果表明 ,CO2 -3 会部分地进入到HAP的晶格结构中 ,形成碳酸羟基磷灰石 .GBC中所生成的HAP晶体在形貌、结构和组成等多方面均与人体骨类似 ,有利于作为生物医用材料的应用 .Glass based bone cement (GBC) was synthesized by mixing CaO-SiO_2-P_2O_5 based glass powder with ammonium phosphate liquid.Phase structure,chemical composition and microstructure of the final products of GBC were measured and observed using X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR) and scanning electron microscopy (SEM) respectively.The results show that with a longer immersion time in simulated body fluid (SBF),the glass phase in GBC gradually changed to hydroxyapatite(HAP).It is also indicated that the crystal formed in GBC belongs to a bone-like hydroxya-canbonate apatite crystallite with the end plane granularity 30～50 nm.Participation of structural carbonate into HAP crystal structure was demonstrated by FTIR.HAP produced in GBC has great similarity in crystal morphology,structure and composition with natural bone HAP.GBC seems to be a greatly desirable biomedical material with high bioacitvity.

关 键 词：玻璃基 生物骨 水泥 羟基磷灰石 生物活性 

分 类 号：TB321[一般工业技术—材料科学与工程]